Active Amyloid- β Vaccination Results in Epigenetic Changes in the Hippocampus of an Alzheimer's Disease-Like Mouse Model.

CONCLUSION: Our results indicate that active Aβ vaccination has significant effects on the epigenome in the hippocampus of APP swe /PS1dE9 mice, and suggest that DNA methylation and hydroxymethylation may be involved in cognitive functioning. PMID: 31453788 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31453788?dopt=Abstract

Source: Current Alzheimer Research - August 26, 2019 Category: Neurology Authors: Lardenoije R, van den Hove DLA, Jung SE, Havermans M, Blackburn P, Liu B, Rutten BPF, Lemere CA Tags: Curr Alzheimer Res Source Type: research