Neutrophil-derived reactive oxygen orchestrates epithelial cell signaling events during intestinal repair

Recent evidence has demonstrated that reactive oxygen, eg, hydrogen peroxide, can activate host cell signaling pathways that function in repair. We show that mice deficient in their capacity to generate reactive oxygen by the Nox2 holoenzyme, an enzyme complex highly expressed in neutrophils and macrophages, have disrupted capacity to orchestrate signaling events that function in mucosal repair. Similar observations were made for mice after neutrophil depletion, pinpointing this cell type as the source of the reactive oxygen driving redox protein signaling in the epithelium.
Source: American Journal of Pathology - Category: Pathology Authors: Tags: Regular Article Source Type: research