Hand therapy or not following collagenase treatment for Dupuytren ’s contracture? Protocol for a randomised controlled trial

Dupuytren ’s contracture (DC) is a fibrotic hand condition in which one or more fingers develop progressive flexion deformities. Quality of life is diminished due to disabling limitations in performing everyday...
Source: BMC Musculoskeletal Disorders - Category: Orthopaedics Authors: Tags: Study protocol Source Type: research

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ConclusionCurrently, the administration of this treatment is promising although long-term studies are necessary to see the real role that this drug can play in both Dupuytren ’s disease and other fibrotic disorders.
Source: Irish Journal of Medical Science - Category: General Medicine Source Type: research
Publication date: November 2019Source: The Journal of Foot and Ankle Surgery, Volume 58, Issue 6Author(s): Jeffrey D. Lehrman, Amy L.L. Miceli, Simon G. Tabchi, Mark A. KaplanAbstractPlantar fibromatosis, also known as Ledderhose's disease, is a rare disorder of benign fibroblast proliferation involving the plantar aponeurosis (i.e., plantar fascia). Traditionally, surgical intervention has been the most common treatment for plantar fibromatosis. However, numerous studies have reported high recurrence rates of plantar fibromatosis after surgical intervention, as well as wound healing difficulties and nerve injury. Plantar ...
Source: The Journal of Foot and Ankle Surgery - Category: Orthopaedics Source Type: research
DiscussionSegmental palmar aponeurectomy as described by Moermans in 1991 improves extension similarly to extensive aponeurectomy but has a lower complication rate. Z-plasty provides good exposure of the pedicles and takes advantage of the greater pliability of the skin on either side of the cord to lengthen the skin by 75%, thereby limiting the risk of the complications seen with needle aponeurotomy. Segmental palmar aponeurectomy with Z-plasty has a role in the management of Dupuytren's disease with flexion contracture predominantly involving the MCPJ.
Source: Orthopaedics and Traumatology: Surgery and Research - Category: Orthopaedics Source Type: research
Publication date: Available online 28 October 2019Source: Hematology/Oncology Clinics of North AmericaAuthor(s): Tony Y. Eng, Mustafa Abugideiri, Tiffany W. Chen, Nicholas Madden, Tiffany Morgan, Daniel Tanenbaum, Narine Wandrey, Sarah Westergaard, Karen Xu
Source: Hematology Oncology Clinics of North America - Category: Hematology Source Type: research
Conclusions: This study demonstrates that treatment of recurrent Dupuytren’s disease is as effective as initial treatment, despite larger extension deficit and worse self-assessed hand function before undergoing repeated treatment. Complication rates were similar for initial and repeated treatments. Furthermore, needle fasciotomy for initial treatment results in better outcomes of repeated treatment compared to patients who initially underwent limited fasciectomy. These findings can be used for a more evidence-based preoperative counseling with patients with recurrent Dupuytren’s disease. CLINICAL QUESTION/L...
Source: Plastic and Reconstructive Surgery - Category: Cosmetic Surgery Tags: Hand/Peripheral Nerve: Original Articles Source Type: research
Publication date: Available online 24 October 2019Source: Joint Bone SpineAuthor(s): Maeva Ferrari, Henri Lellouche, Eric Roulot, Alain Yelnik, Thomas Bardin, Philippe Orcel, Pascal Richette, Johann Beaudreuil
Source: Joint Bone Spine - Category: Orthopaedics Source Type: research
Conclusion The pathophysiological changes involved in Dupuytren’s disease can be divided into a number of molecular and structural alterations with genetic predisposition playing a contributory role. Understanding these changes can allow for the development of biologics which may disrupt and halt the disease process.
Source: Annals of Plastic Surgery - Category: Cosmetic Surgery Tags: Review Paper Source Type: research
Conditions:   Dupuytren's Disease;   Dupuytren Contracture;   Dupuytren Disease of Palm and Finger;   Dupuytren Disease of Finger;   Dupuytrens Contracture of Both Hands;   Dupuytren's Disease of Palm of Right Hand;   Dupuytren's Disease of Palm of Left Hand;   Dupuytren Cont racture of Right Palm;   Dupuytren Contracture of Left Palm;   Dupuytren's Contracture Left;   Dupuytren's Contra...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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