Canagliflozin Improves Erythropoiesis in Diabetes Patients with Anemia of Chronic Kidney Disease

Diabetes Technology&Therapeutics, Ahead of Print.
Source: Diabetes Technology - Category: Endocrinology Authors: Source Type: research

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Heart failure (HF) and chronic kidney disease (CKD) co-exist, and it is estimated that about 50% of HF patients suffer from CKD. Although studies have been performed on the association between CKD and HF with reduced ejection fraction (HFrEF), less is known about the link between CKD and HF with preserved ejection fraction (HFpEF). Approximately 50% of all patients with HF suffer from HFpEF, and this percentage is projected to rise in the coming years. Therapies for HFrEF are long established and considered quite successful. In contrast, clinical trials for treatment of HFpEF have all shown negative or disputable results. ...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
AbstractBackgroundNondipping heart rate (NHR) is a condition reported to be associated with cardiovascular events and cardiovascular mortality recently. We aimed to search whether there is difference among hypertensive patients with and without chronic kidney disease (CKD) in terms of NHR pattern and the factors associated with NHR in patients with CKD.MethodsThe study included 133 hypertensive patients with normal kidney functions, 97 hypertensive patients with predialysis CKD, and 31 hypertensive hemodialysis patients. Heart rate, blood pressure and pulse wave velocity (PWV) were measured by 24-h ambulatory blood pressur...
Source: Clinical and Experimental Nephrology - Category: Urology & Nephrology Source Type: research
Diabetes Technology&Therapeutics, Ahead of Print.
Source: Diabetes Technology and Therapeutics - Category: Endocrinology Authors: Source Type: research
Chronic kidney disease (CKD), defined by low estimated glomerular filtration rate (eGFR), is common and a risk factor for cardiovascular disease (CVD). The risk rises with decline in eGFR and is maximal (around 20 times that of the general population) in patients with end-stage kidney disease (ESKD) requiring dialysis. Conventional factors such as diabetes mellitus, hypertension, smoking and hyperlipidaemia contribute to the risk of progressive CKD and CVD. Other factors including proteinuria, left ventricular hypertrophy, impaired calcium –phosphate homeostasis (PTH, FGF-23), anaemia and inflammation, contribute to ...
Source: Medicine - Category: Internal Medicine Authors: Tags: Chronic kidney disease Source Type: research
Abstract A retrospective study was conducted over seven years and it aimed to find out various causes of anemia among patients with chronic kidney disease (CKD). The study included nondialysis-dependent adult CKD patients who underwent anemia evaluation. A total of 584 patients were studied. Three hundred and twenty-one (55%) patients were male and 263 (45%) were female. The mean age of the patients was 55.5 ± 14 years. One hundred and seventy-eight (30.5%) had a diabetic CKD and 406 (69.5%) had a nondiabetic CKD. Seventy-two (12.3%) patients were in CKD Stage 3, 193 (33%) patients in CKD Stage 4, and 319 (...
Source: Saudi Journal of Kidney Diseases and Transplantation - Category: Urology & Nephrology Authors: Tags: Saudi J Kidney Dis Transpl Source Type: research
Authors: Wee YH, Anpalahan M Abstract BACKGROUND: Older age has a significant association with anaemia. However, this has not been adequately investigated in the context of specific comorbidities such as type 2 diabetes mellitus(T2DM). OBJECTIVES: To investigate the role of age in normocytic anaemia(NCA) and the adverse outcomes of NCA in T2DM. METHODS: Patients with NCA, either unexplained or related to chronic kidney disease(CKD), were recruited from a diabetic clinic over six months. Anaemia was defined as a haemoglobin(Hb)
Source: Current Aging Science - Category: Geriatrics Tags: Curr Aging Sci Source Type: research
AbstractCardiovascular disease (CVD) continues to be the leading cause of death in Western civilizations, and hyperlipidemia is a well-established independent risk factor for the development of atherosclerosis and CVD progression. Many chronic kidney disease (CKD) and dialysis patients have the traditional CVD risk factors (age, obesity, hypertension, diabetes mellitus, and hyperlipidemia); however, CKD and dialysis predispose patients to several non-traditional risk factors, including myocardial remodeling, hyperparathyroidism, malnutrition, bone and mineral disorders, anemia, albuminuria, inflammation, and endothelial dy...
Source: Drugs and Therapy Perspectives - Category: Drugs & Pharmacology Source Type: research
Conclusion: A BMI-based cross-classification approach, which provides more comprehensive findings than that in previous approaches, is expected to be an effective method for evaluating renal prognostic factors in patients with CKD who are affected by multiple risk factors.Kidney Blood Press Res
Source: Kidney and Blood Pressure Research - Category: Urology & Nephrology Source Type: research
Conclusion: Our findings describe the most reported risk factors for preventability of oral anticoagulant-induced bleedings. These factors may be useful for targeting interventions to improve pharmacovigilance activities in our regional territory and to reduce the burden of medication errors and inappropriate prescription. Introduction Oral anticoagulant therapy is widely used for the prevention of stroke and systemic embolism in patients with atrial fibrillation, or for the prevention and treatment of deep vein thrombosis and pulmonary embolism (Raj et al., 1994; Monaco et al., 2017). Oral anticoagulants can be di...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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