HIV-Nef Protein Transfer to Endothelial Cells Requires Rac1 Activation and Leads to Endothelial Dysfunction: Implications for Statin Treatment in HIV Patients.

Conclusions: These studies establish a mechanism by which HIV-Nef persistence despite ART could contribute to ongoing HIV related vascular dysfunction which may then be ameliorated by statin treatment. PMID: 31451038 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31451038?dopt=Abstract

Source: Circulation Research - August 26, 2019 Category: Cardiology Authors: Chelvanambi S, Gupta SK, Chen X, Ellis BW, Maier BF, Colbert TM, Kuriakose J, Zorlutuna P, Jolicoeur P, Obukhov AG, Clauss M Tags: Circ Res Source Type: research