Continued exposure of anti-cancer drugs to human iPS cell-derived cardiomyocytes can unmask their cardiotoxic effects

Publication date: Available online 27 August 2019Source: Journal of Pharmacological SciencesAuthor(s): Kazuho Sakamoto, Kohei Sakatoku, Shintaro Sugimoto, Nanami Iwasaki, Yusuke Sano, Masahiko Yamaguchi, Junko KurokawaAbstractAlthough the cardiotoxicity of anti-cancer drugs is an important issue, the underlying mechanisms remain unknown. To develop a sensitive assay system for cardiotoxicity, we examined effects of anti-cancer drugs on contractile functions of human iPS cell-derived cardiomyocytes by using non-invasive motion field imaging analysis with extended drug exposure time. We succeeded in continuously measuring stable contractile function. The continued exposure revealed that the difference in cardiotoxicity between cardiotoxic doxorubicin and less toxic erlotinib was more evident after 8 days of treatment than with 3 days of treatment, suggesting that continued exposure improved the predictive power for cardiotoxicity of anti-cancer drugs.
Source: Journal of Pharmacological Sciences - Category: Drugs & Pharmacology Source Type: research