Disruptor Profile: Jayne Mackta

I can’t remember how or when I met Jayne Mackta, but I’ve always been grateful I did and I hope you’ll agree when I introduce her to you today. Jayne is an entrepreneur, pursuing the kinds of niche needs that – at their core – are the underpinnings of the discoveries in biomedicine that we depend upon to heal us when we’re ill. She’s one of many, I’m sure, but is one of the best (I’m sure of that, too). She not only works in the ‘trenches,’ but often goes there first and digs them herself to support the many others who will come later. Her most recent effort, Curious Young Writers, is the latest of her (ad)ventures in supporting healing endeavors. In my book, Covenants, Inspiring the Soul of Healing, I say that anyone who touches health care in any way is a healer. Jayne certainly qualifies. Jayne Mackta Jayne, I know you’ve been at this for a while. How can you continue to be so willing to tackle seemingly impossible problems and shove aside the barriers that others find defeating? Jayne Mackta: I have been an advocate for biomedical research my entire adult life. As the mother of a child with Gaucher’s disease and secondary pulmonary hypertension, I know the issues and have dedicated myself to helping patients and families affected by genetic disorders. That’s why I served as President of the National Tay-Sachs &Allied Diseases Association for seven years. I also helped organize an...
Source: Disruptive Women in Health Care - Category: Health Medicine and Bioethics Commentators Authors: Tags: Uncategorized biomedical research Genetic Alliance Source Type: blogs

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Sialyl Lewis A (sLeA, also known as CA19-9), a tetrasaccharide selectively and highly expressed on advanced adenocarcinomas including colon, stomach, and pancreatic cancers, has long been considered as an attractive target for active and passive vaccination. While progress in antibodies targeting tumor-associated protein antigens resulted in an impressive array of therapeutics for cancer treatment, similar progress in exploiting tumor-associated carbohydrate antigens, such as sLeA, has been hampered by the lack of a detailed understanding of the singular characteristics of these antigens. We have addressed this issue by an...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Despite recent therapeutic advances, prostate cancer remains a leading cause of cancer-related death. A subset of castration-resistant prostate cancers become androgen receptor (AR) signaling independent and develop neuroendocrine prostate cancer (NEPC) features through lineage plasticity. These NEPC tumors, associated with aggressive disease and poor prognosis, are driven, in part, by aberrant expression of N-Myc, through mechanisms that remain unclear. Integrative analysis of the N-Myc transcriptome, cistrome, and interactome using in vivo, in vitro, and ex vivo models (including patient-derived organoids) identified a l...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
In a society where physical activity is limited and food supply is abundant, metabolic diseases are becoming a serious epidemic. Metabolic syndrome (MetS) represents a cluster of metabolically related symptoms such as obesity, hypertension, dyslipidemia, and carbohydrate intolerance, and significantly increases type 2 diabetes mellitus risk. Insulin resistance and hyperinsulinemia are consistent characteristics of MetS, but which of these features is the initiating insult is still widely debated. Regardless, both of these conditions trigger adverse responses from the pancreatic β cell, which is responsible for produci...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Induction of memory CD8+ T cells is important for controlling infections such as malaria and HIV/AIDS and for cancer immunotherapy. Accurate assessment of antigen-specific (Ag-specific) CD8+ T cells is critical for vaccine optimization and for defining correlates of protection. However, conditions for determining Ag-specific CD8+ T cell responses ex vivo using intracellular cytokine staining (ICS) may be variable, especially in humans with complex antigens. Here, we used an attenuated whole parasite malaria vaccine model in humans and various experimental infections in mice to show that the duration of antigenic stimulatio...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
New J. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9NJ03653A, PaperHuiping Wang, Libang He, Peng Zhang, Jie Zhang, Zhenhua Chen, Xiuli Ren, Xifan Mei Targeted delivery of therapeutic drug into cancer cells is a facile method to improve the therapeutic efficacy. Focused on this point, the doxorubicin (DOX) -loaded hydroxyapatite (HAP) nanorods consisting of... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - New J. Chem. latest articles - Category: Chemistry Authors: Source Type: research
Chem. Commun., 2019, Accepted Manuscript DOI: 10.1039/C9CC05826E, CommunicationJia Li, Le Li Zeng, Kai Xiong, Thomas Wheildon Rees, Chengzhi Jin, Weijun Wu, Yu Chen, Liangnian Ji, Hui Chao Platinum-resistant cancer cells are sensitive to changes in the levels of reactive oxidative species (ROS). Herein, we design a biotin-modified Ru(II) complex as photosensitizer (denoted as Ru-Biotin). Ru-Biotin can selectively... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - Category: Chemistry Authors: Source Type: research
Chem. Commun., 2019, Accepted Manuscript DOI: 10.1039/C9CC03379C, CommunicationAnnemiek Uvyn, Ruben De Coen, Olivier De Wever, Kim Deswarte, Bart Lambrecht, Bruno De Geest Triggering antibody-mediated innate immune mechanisms to kill cancer cells is an attractive therapeutic avenue. In this context, recruitment of endogenous antibodies to the cancer cell surface could be a viable... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - Category: Chemistry Authors: Source Type: research
Publication date: Available online 19 August 2019Source: The American Journal of SurgeryAuthor(s): Katherine Bingmer, Asya Ofshteyn, David Dietz, Sharon L. Stein, Emily SteinhagenAbstractBackgroundImmunosuppressed patients have an increased risk of developing anal cancer, but little data exists regarding outcomes of this population.MethodsA retrospective review of anal cancer patients at a single academic institution from 2006-2017 was performed.Results19 (14%) of 136 anal cancer patients were immunosuppressed. Immunosuppressed patients were more likely to be hypoalbuminemic (21% vs. 6%, p=0.025), less likely to complete c...
Source: The American Journal of Surgery - Category: Surgery Source Type: research
ConclusionsAbdominal wall defects from resection of cancerous masses of the abdominal wall can be closed with a contralateral rectus abdominis muscle transplant in the absence of mesh.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
Source: Radiologia Brasileira - Category: Radiology Source Type: research
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