Poly(ADP-Ribose) Polymerase 2 Recruits Replication Protein A to Sites of LINE-1 Integration to Facilitate Retrotransposition

Poly(ADP-ribose) polymerase 2 and the replication protein A (RPA) complex are sequentially recruited to L1 insertion sites to facilitate integration. RPA can protect single-strand L1 cDNA integration intermediates from APOBEC3-mediated cytosine deamination but also may provide a conduit to guide APOBEC3 proteins to L1 integration sites to restrict retrotransposition.

Source: Molecular Cell - August 27, 2019 Category: Cytology Authors: Tomoichiro Miyoshi, Takeshi Makino, John V. Moran Tags: Article Source Type: research