Mechanisms of action of low-dose IL-2 restoration therapies in SLE.

Mechanisms of action of low-dose IL-2 restoration therapies in SLE. Curr Opin Immunol. 2019 Aug 23;61:39-45 Authors: Ballesteros-Tato A, Papillion A Abstract Interleukin-2 (IL-2) shortage is a hallmark of Systemic Lupus Erythematosus (SLE). Importantly, clinical and preclinical studies demonstrate the potential clinical benefits of IL-2-based restoration therapies for the treatment of SLE. Here we discuss the immunological consequences of IL-2 deficiency in SLE patients and the mechanisms underlying the therapeutic effects of low-dose IL-2 regimens. PMID: 31450016 [PubMed - as supplied by publisher]
Source: Current Opinion in Immunology - Category: Allergy & Immunology Authors: Tags: Curr Opin Immunol Source Type: research

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