Mechanisms of action of low-dose IL-2 restoration therapies in SLE.
Mechanisms of action of low-dose IL-2 restoration therapies in SLE.
Curr Opin Immunol. 2019 Aug 23;61:39-45
Authors: Ballesteros-Tato A, Papillion A
Abstract
Interleukin-2 (IL-2) shortage is a hallmark of Systemic Lupus Erythematosus (SLE). Importantly, clinical and preclinical studies demonstrate the potential clinical benefits of IL-2-based restoration therapies for the treatment of SLE. Here we discuss the immunological consequences of IL-2 deficiency in SLE patients and the mechanisms underlying the therapeutic effects of low-dose IL-2 regimens.
PMID: 31450016 [PubMed - as supplied by publisher]
Source: Current Opinion in Immunology - Category: Allergy & Immunology Authors: Ballesteros-Tato A, Papillion A Tags: Curr Opin Immunol Source Type: research