Endothelin 1 and 3 induce choleresis in the rat through ETB receptors coupled to nitric oxide and vago-vagal reflexes

Conclusion: ET-1 and 3 induced choleresis mediated by ETB receptors coupled to nitric oxide release and vago-vagal reflexes without involving hemodynamic changes. ET-induced choleresis seems to be caused by increased plasma membrane translocation and transcriptional expression of key bile transporters. These findings indicate that ETs are able to elicit hemodynamic-independent biological effects in the liver and suggest that these peptides may play a beneficial role in pathophysiological situations where bile secretion is impaired.

Source: Clinical Science - May 3, 2013 Category: Biomedical Science Authors: M R Rodriguez, L R Soria, M S Ventimiglia, A C Najenson, A di Maria, P Dabas, A Fellet, R A Marinelli, M S Vatta, L G Bianciotti Source Type: research