IJERPH, Vol. 16, Pages 3134: Chemical Effect of Bisphenol A on Non-Alcoholic Fatty Liver Disease

IJERPH, Vol. 16, Pages 3134: Chemical Effect of Bisphenol A on Non-Alcoholic Fatty Liver Disease International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16173134 Authors: Marcello Dallio Nadia Diano Mario Masarone Antonietta Gerarda Gravina Vittorio Patanè Mario Romeo Rosa Di Sarno Sonia Errico Carla Nicolucci Ludovico Abenavoli Emidio Scarpellini Luigi Boccuto Marcello Persico Carmelina Loguercio Alessandro Federico Non-alcoholic fatty liver disease (NAFLD) is considered a predominant chronic liver disease worldwide and a component of metabolic syndrome. Due to its relationship with multiple organs, it is extremely complex to precisely define its pathogenesis as well as to set appropriate therapeutic and preventive strategies. Endocrine disruptors (EDCs) in general, and bisphenol A (BPA) in particular, are a heterogeneous group of substances, largely distributed in daily use items, able to interfere with the normal signaling of several hormones that seem to be related to type 2 diabetes mellitus (T2DM), obesity, and other metabolic disorders. It is reasonable to hypothesize a BPA involvement in the pathogenesis and evolution of NAFLD. However, its mechanisms of action as well as its burden in the vicious circle that connects obesity, T2DM, metabolic syndrome, and NAFLD still remain to be completely defined. In this review we analyzed the scientific evidence on this promising research area, in order to provide ...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Review Source Type: research