The Trials within Cohorts design faced methodological advantages and disadvantages in the exercise oncology setting

The Trials within Cohorts (TwiCs) design is an alternative for pragmatic randomized controlled trials (RCTs) and might overcome disadvantages such as difficult recruitment, dropout after randomization to control, and contamination. We investigated the applicability of the TwiCs design in an exercise oncology study regarding the recruitment process, representativeness of the study sample, contamination, participation, and dropout.

Source: Journal of Clinical Epidemiology - May 26, 2019 Category: Epidemiology Authors: Roxanne Gal, Evelyn M. Monninkhof, Carla H. van Gils, Rolf H.H. Groenwold, Desir ée H.J.G. van den Bongard, Petra H.M. Peeters, Helena M. Verkooijen, Anne M. May Tags: Original Article Source Type: research