High risk for cardiovascular disease in postmenopausal breast cancer survivors
Objective:
Breast cancer patients have a higher mortality risk of cardiovascular disease (CVD) than women from the general population. CVD risk may increase significantly in postmenopausal women with early-stage breast cancer. The aim of this study was to evaluate risk factors for CVD in postmenopausal breast cancer survivors.
Methods:
In this cross-sectional study, 96 postmenopausal breast cancer survivors were compared with 192 postmenopausal women. The main group included women with amenorrhea>12 months, aged ≥45 years, with breast cancer, and without established CVD. The control group fulfilled the same criteria, but did not have breast cancer. Groups were matched by age, time since menopause, and body mass index, in a ratio of 1 case to 2 controls (1:2). Women with three or more of the following criteria were diagnosed with metabolic syndrome: waist circumference>88 cm; triglycerides ≥150 mg/dL; high-density lipoprotein cholesterol 1 mm) of the carotid arteries and/or the presence of atheromatous plaque assessed by carotid artery ultrasound (scanner duplex).
Results:
Breast cancer patients had higher HSP60 levels and lower HSP70 levels than controls (P
Source: Menopause - Category: OBGYN Tags: Original Articles Source Type: research
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