Allogeneic Bone Marrow Transplantation versus Peripheral Blood Stem Cell Transplantation for Hematologic Malignancies in Children: A Systematic Review and Meta-Analysis

Hematopoietic cell transplantation is an essential and often the sole treatment strategy for relapsed and refractory hematologic malignancies. Patients and health care professionals expect to achieve long-term survival with intensive chemotherapy, total body irradiation, and allogeneic immune reactions caused by the graft-versus-leukemia effect [1]. Controlling treatment-related mortality is also key to successful hematopoietic cell transplantation. Adverse events after hematopoietic cell transplantation include the immune reaction called graft-versus-host disease (GVHD); bacterial, viral, and fungal infections; and hepatic sinusoidal obstruction syndrome [1].
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research

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AbstractBackground Patients with haematological malignancies are at high risk of invasive fungal infections. However, there is a lack of information about the utilisation of the recommended Australian antifungal prophylaxis guidelines in haematology outpatients.Objective To assess the impact of a weekly pharmacist review of high-risk adult haematology outpatients on the utilisation of appropriate antifungal prophylaxis.Setting Outpatient cancer centre, tertiary referral hospital in Sydney, Australia.Method A 3-month pre-and post-interventional study was conducted. A retrospective audit was conducted to obtain baseline util...
Source: International Journal of Clinical Pharmacy - Category: Drugs & Pharmacology Source Type: research
Conclusions: Although morphological and biochemical tests are still used, they are associated with high-throughput sequencing techniques, due to their accuracy and time saving for profiling the predominant species in oral mycobiome. PMID: 32944157 [PubMed]
Source: Journal of Oral Microbiology - Category: Microbiology Tags: J Oral Microbiol Source Type: research
Publication date: Available online 21 August 2020Source: Clinical Lymphoma Myeloma and LeukemiaAuthor(s): Michael Ozga, Ying Huang, James S. Blachly, Nicole R. Grieselhuber, Sarah Wall, Karilyn Larkin, Tamanna Haque, Alison R. Walker, Bhavana Bhatnagar, Gregory Behbehani, Sumithira Vasu, Joseph E. Maakaron, Mark Lustberg, Alice S. Mims
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research
Oral candidiasis is the most common fungal infection and one of its rarest forms is hyperplasia. It usually occurs in individuals with generalized immunosuppression and vitamin deficiency. This paper reports a case of a male patient, 3 years old, diagnosed with acute lymphocytic leukemia pre-B and undergoing chemotherapy for about a year. During the maintenance phase, he presented an exophytic, asymptomatic, pediculated, pale lesion, extending through the lingual dorsum. The chemotherapeutic treatment was interrupted to clarify the diagnosis after an incisional biopsy.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - Category: ENT & OMF Authors: Tags: 20190858 Source Type: research
Publication date: Available online 21 August 2020Source: Clinical Lymphoma Myeloma and LeukemiaAuthor(s): Michael Ozga, Ying Huang, James S. Blachly, Nicole R. Grieselhuber, Sarah Wall, Karilyn Larkin, Tamanna Haque, Alison R. Walker, Bhavana Bhatnagar, Gregory Behbehani, Sumithira Vasu, Joseph E. Maakaron, Mark Lustberg, Alice S. Mims
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research
The aim of our study was to selectively analyze newly diagnosed patients with acute myeloid leukemia treated with a hypomethylating agent and establish their risk for developing invasive fungal infections (IFIs). We stratified patients into concern for IFI versus no concern, and observed that patients of the male gender and those with underlying chronic obstructive pulmonary disease are at higher risk for concern for IFI, which may prompt clinicians to consider anti-mold prophylaxis in this setting.
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Tags: Original Study Source Type: research
This report presents the clinical features in terms of chest CT scan images which may be used to identify cases of HCoV-OC43 infection induced pneumonia in immunocompromised children. Patient concerns: We report here a girl with acute lymphoblastic leukemia who developed respiratory symptoms during febrile neutropenia. Rapid clinical progression and nodular lesions on her chest X-ray and computed tomography scans were suggestive of a pulmonary fungal infection. Diagnosis: A series of tests eventually confirmed the exclusive presence of HCoV-OC43 by the FilmArray Respiratory Panel from a throat swab sample. Intervent...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
Allogeneic hematopoietic cell transplantation (HCT) remains the only curable option for adult patients with hematologic malignancies. According to guidelines published by the American Society for Transplantation and Cellular Therapy, allogeneic HCT should be offered to all intermediate ‐ and high‐risk patients with acute leukemia. While matched‐related donor (MRD) grafts continue to be the preferred stem cell source for allogeneic HCT, studies comparing MRD grafts to matched‐unrelated donor (MUD) grafts showed comparable outcomes in patients with acute leukemia. Unfortunat ely, for those without a suitable matched...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - Category: Drugs & Pharmacology Authors: Tags: Si On Stem Cell Transplantation Source Type: research
Publication date: Available online 26 June 2020Source: Clinical Lymphoma Myeloma and LeukemiaAuthor(s): Jessie Signorelli, Matthew Lei, Jenna Lam, Marla Jalbut, Philip C. Amrein, Amir T. Fathi, Gabriela Hobbs, Hanno Hock, Steven Lawrence McAfee, Alyssa R. Letourneau, Rupa Narayan, Andrew Brunner
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research
AbstractWith the advent of new targeted drugs in hematology and oncology patient prognosis is improved. Combination with antifungal prophylaxis challenges clinicians due to pharmacological profiles prone to drug –drug interactions (DDI). Midostaurin is a novel agent forFLT3-TKD/-ITDmut-acute myeloid leukemia (AML) and metabolized via cytochrome P450 3A4 (CYP3A4). Posaconazole is a standard of care antifungal agent used for prophylaxis during induction treatment of AML and a strong CYP3A4 inhibitor. Concomitant administration of both drugs leads to elevated midostaurin exposure. Both drugs improve overall survival at ...
Source: Annals of Hematology - Category: Hematology Source Type: research
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