Two new sarpagine-type indole alkaloids and antimalarial activity of 16-demethoxycarbonylvoacamine from Tabernaemontana macrocarpa Jack

AbstractTwo new sarpagine-type indole alkaloids (1 and2), together with five known alkaloids; 12-methoxy-4-methylvoachalotine (3), 16-demethoxycarbonylvoacamine (4), isositsirikine (5), affinisine (6), affinine (7), were isolated from the bark ofTabernaemontana macrocarpa Jack. The structures of these alkaloids were determined based on spectroscopic data, chemical correlation, and comparison with the literature. 16-Demethoxycarbonylvoacamine (4) showed antiplasmodial activities againstPlasmodium falciparum 3D7 and cytotoxic activities against human cell line, HepG2 cells.
Source: Journal of Natural Medicines - Category: Drugs & Pharmacology Source Type: research