A Portion of Inhibitory Neurons in Human Temporal Lobe Epilepsy are Functionally Upregulated: An Endogenous Mechanism for Seizure Termination.

CONCLUSION: Automatic seizure termination is likely due to a fact that a portion of the inhibitory neurons and synapses are upregulated in the seizure-onset cortices. This mechanism may create novel therapeutic strategies to treat intractable epilepsy, such as the simultaneous upregulation of cortical inhibitory neurons and their output synapses. PMID: 25475128 [PubMed - as supplied by publisher]
Source: CNS Neuroscience and Therapeutics - Category: Neuroscience Authors: Tags: CNS Neurosci Ther Source Type: research

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In this study the effects of caffeine exposure on the pentylenetetrazole (PTZ) induced seizure thresholds and seizure stages in the Wistar and genetic absence epilepsy model offsprings were examined. Adult female and male Wistar rats and genetic absence epilepsy rats from Strasbourg (GAERS) consumed caffeine dissolved in water (0.3 g/L) before conception, during the gestational periods and lactation period whereas control groups of each strain received tap water. All offsprings at postnatal day 30 (PN30) subjected to 70 mg/kg of PTZ were evaluated in terms of overall seizure stages, the latency to the first g...
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
Publication date: January 2020Source: Biomedical Signal Processing and Control, Volume 55Author(s): Evelien E. Geertsema, Gerhard H. Visser, Josemir W. Sander, Stiliyan N. KalitzinAbstractCentral apneas occurring in the aftermath of epileptic seizures may lead to sudden death. Contact-sensors currently used to detect apneas are not always suitable or tolerated. We developed a robust automated non-contact algorithm for real-time detection of central apneas using video cameras. One video recording with simulated apneas and nine with real-life apneas associated with epileptic seizures, each recorded from 3 to 4 angles, were u...
Source: Biomedical Signal Processing and Control - Category: Biomedical Science Source Type: research
Conclusion: The present meta-analysis shows that the CRP levels in peripheral blood were significantly increased in epileptic patients compared to healthy controls, indicating a significant association between inflammation and epilepsy. Epileptic seizures may be associated with the inflammatory response.
Source: Frontiers in Neurology - Category: Neurology Source Type: research
ConclusionThe observed response rate in this study is similar to placebo rates in prospective randomized trials of pharmaceutical grade products and the withdrawal rate is greater than rates obtained with retrospective methods. Doses of OCE administered were lower than doses used in randomized trials.
Source: Seizure - Category: Neurology Source Type: research
Neuropediatrics DOI: 10.1055/s-0039-1697621We herein report the case of a 3-year-old girl with severe myoclonic epilepsy of infancy known as Dravet syndrome (DS) on a ketogenic diet (KD) whose glucose concentrations were controlled by using a flash glucose monitoring system. Two-hundred ninety-three events of moderate hypoglycemia with a minimum of 45 mg/dL, not related to day or night, were recorded during the observational period. Hypoglycemia rate declined from 24.5% of all measurements to 11.8% over time; one hypoglycemia-associated seizure and one seizure due to ketone concentrations below the therapeutic range...
Source: Neuropediatrics - Category: Neurology Authors: Tags: Short Communication Source Type: research
Neurological disease encompasses a broad spectrum of conditions which may be affected by pregnancy, present de novo in pregnancy, or are caused by the pregnancy itself. In the UK, 9.8 women in 100,000 died during pregnancy or up to 42 days after delivery (Mothers and Babies Reducing Risk through Confidential Enquiry (MBRRACE) report 2018). Neurological diseases, including epilepsy and stroke, continues to be the second leading indirect cause of maternal mortality and the numbers have not changed since reporting began in 1985, despite the availability of easily accessible Green-top Guidelines on the management of epilepsy t...
Source: Obstetrics, Gynaecology and Reproductive Medicine - Category: OBGYN Authors: Tags: Review Source Type: research
Authors: Fernandes MJS, Carletti CO, Sierra de Araújo LF, Santos RC, Reis J Abstract A growing number of studies have shown that exposure to air pollutants such as particulate matter and gases can cause cardiovascular, neurodegenerative and psychiatric diseases. The severity of the changes depends on several factors such as exposure time, age and gender. Inflammation has been considered as one of the main factors associated with the generation of these diseases. Here we present some cellular mechanisms activated by air pollution that may represent risk factors for epilepsy and drug resistance associated to e...
Source: Revue Neurologique - Category: Neurology Tags: Rev Neurol (Paris) Source Type: research
ConclusionThis case highlights the importance of genetics shaping phenotypes and that consideration should always be given to a full relevant family history.  It also shows a rare case of rapidly progressive dementia confirmed due to CJD with a likely underlying familial predisposition.
Source: Age and Ageing - Category: Geriatrics Source Type: research
Journal of Perinatology, Published online: 16 September 2019; doi:10.1038/s41372-019-0494-7Association of perinatal factors of epilepsy in very low birth weight infants, using a nationwide database in Japan
Source: Journal of Perinatology - Category: Perinatology & Neonatology Authors: Source Type: research
Interest in cannabis as a treatment for people living with epilepsy has increased over the last several years. The use of cannabis for epilepsy has been described in anecdotal reports for centuries. [1 –3] Colorado voters passed a medicinal cannabis law allowing use for specific diagnoses in November 2000. Despite many new treatments becoming available in the last 20 years, including new antiseizure medications, neurostimulation, and improvements in surgical techniques and etiologic identificati on, many children living with epilepsy do not have well-controlled seizures.
Source: Seizure: European Journal of Epilepsy - Category: Neurology Authors: Source Type: research
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