A Portion of Inhibitory Neurons in Human Temporal Lobe Epilepsy are Functionally Upregulated: An Endogenous Mechanism for Seizure Termination.

CONCLUSION: Automatic seizure termination is likely due to a fact that a portion of the inhibitory neurons and synapses are upregulated in the seizure-onset cortices. This mechanism may create novel therapeutic strategies to treat intractable epilepsy, such as the simultaneous upregulation of cortical inhibitory neurons and their output synapses.
PMID: 25475128 [PubMed - as supplied by publisher]

Source: CNS Neuroscience and Therapeutics - December 5, 2014 Category: Neuroscience Authors: Wen B, Qian H, Feng J, Ge RJ, Xu X, Cui ZQ, Zhu RY, Pan LS, Lin ZP, Wang JH Tags: CNS Neurosci Ther Source Type: research