MRI characteristics predict the efficacy of meloxicam treatment in patients with desmoid ‐type fibromatosis

This study aimed to determine the clinical significance of MRI characteristics as a possible predictor of responsiveness to meloxicam treatment in patients with desmoid ‐type fibromatosis (DF). Additionally, it analysed the correlation between CTNNB1 mutation status and signal intensity of MRI.MethodsForty ‐six patients consecutively treated with meloxicam composed this study. The low‐intensity area (LIA) on T2‐weighted MRI was determined. We divided patients into two groups based on the efficacy of meloxicam: a clinical benefit group (CB group, including CR: complete response; PR: partial respo nse; and SD: stable disease) and non‐clinical benefit group (NB group, including PD: progressive disease). Correlations of the efficacy with LIA and CTNNB1 mutation status with LIA were investigated.ResultsIn total, 11, 17 and 18 patients showed PR, SD and PD, respectively. The mean LIA ratio before treatment was significantly higher (P 
Source: Journal of Medical Imaging and Radiation Oncology - Category: Radiology Authors: Tags: Medical Imaging —Radiation Oncology—Original Article Source Type: research

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A 42-year-old woman presented with a clinically obvious giant rhinophyma. The protocol of the unit handling the case mandated that all lesions amenable to biopsy should have a core biopsy before any definitive surgery, but the unnecessary biopsy was not representative and suggested an incorrect diagnosis of perifollicular fibroma. The lesion was excised. The sections showed dilated hair follicle pores on the skin surface, squamous lined hair follicles plugged with keratin, prominent sebaceous glands, perifollicular inflammation without granulomas, intradermal budding of hair follicle basal cells, and extensive hypocellular...
Source: Advances in Anatomic Pathology - Category: Pathology Tags: AMR Series Source Type: research
Authors: Gong L, Bui MM, Zhang W, Sun X, Zhang M, Yi D Abstract H3F3A mutations and the expression of glycine 34 to tryptophan (G34W) mutants in giant cell tumors of bone (GCTBs) and other bone tumors were detected to compare H3F3A mutation types and the expression of G34W-mutant protein in order to provide a theoretical basis for using H3F3A mutations as a diagnostic and differential-diagnostic tool for GCTBs. A total of 366 bone tumor cases were investigated. The cases involved 215 men and 151 women, whose median age was 29 years (3-84). The cases included GCTB (n=180), recurrent GCTB (n=19), GCTB with lung metas...
Source: Histology and Histopathology - Category: Cytology Tags: Histol Histopathol Source Type: research
Publication date: Available online 30 September 2020Source: Journal of Oral and Maxillofacial Surgery, Medicine, and PathologyAuthor(s): Rudra Deo Kumar, Anjali Verma, Sujata Mohanty, Saroj Kumari, Itrat Hussain, Sujoy Ghosh
Source: Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology - Category: ENT & OMF Source Type: research
ConclusionsDiagnosis can be established in asymptomatic young patients through a congruent physical exam, regular analytic results and imaging tests that simply show swelling of soft tissue —a biopsy is generally not required for diagnosis. As pachydermodactyly’s course is asymptomatic and benign, knowledge about this condition is limited, which increases the likelihood of its underdiagnosis—it is important that clinicians know of pachydermodactyly in order to avoid misdiagnosis.
Source: Irish Journal of Medical Science - Category: General Medicine Source Type: research
The aim of this study was to report the clinicopathologic features of 62 cases of central odontogenic fibroma (COdF).
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - Category: ENT & OMF Authors: Tags: Original Article Source Type: research
AbstractFibroepithelioma of Pinkus (FEP) is a subtype of basal cell carcinoma (BCC) that can clinically resemble intradermal nevi (IDN) and fibromas. We performed a retrospective review of consecutively biopsied lesions confirmed to be FEP on histopathology diagnosed from January 1, 2008 to April 8, 2019. Clinical (n = 48), contact non-polarized dermoscopy (NPD) (n = 44), and contact polarized dermoscopy (PD) (n = 22) images from 36 patients were reviewed. Mean age was 64.5 years (SD 15.1 years, range 24–86 years) at diagnosis of first FEP lesion. Most lesions ...
Source: Archives of Dermatological Research - Category: Dermatology Source Type: research
Hereditary gingival fibromatosis (HGF) is a rare oral condition that may appear as an isolated entity or as part of a genetic disease or syndrome. Molecular and biochemical mechanisms that trigger this pathologic process are not completely understood. In this article, we present a rare case of hereditary gingival fibromatosis in conjunction with a syndromic phenotype, associated with a rare missense mutation of the KCNK4 gene. This mutation induces a change in the structure of the TRAAK channel belonging to the 2-pore potassium channels.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - Category: ENT & OMF Authors: Tags: Case Report Source Type: research
ConclusionThe findings showed that tongue biopsied lesions had low frequency. Irritation fibroma, SCC and OLP were the most common lesions with a female predilection. By comparing the present results with other epidemiologic studies, it revealed valuable data, which can be useful for dental practitioners.
Source: Journal of Maxillofacial and Oral Surgery - Category: ENT & OMF Source Type: research
The molecular pathogenesis of mixed odontogenic tumors has not been established and understanding their genetic basis could refine their classification and help define molecular markers for diagnostic purposes. We assessed potentially pathogenic mutations in the component tissues of 28 cases of mixed odontogenic tumors. Laser capture microdissected tissue from ten ameloblastic fibromas (AF), four ameloblastic fibrodentinomas (AFD), six ameloblastic fibro-odontomas (AFO), three ameloblastic fibrosarcomas (AFS), and five odontomas (OD) were screened by next-generation sequencing for a panel of 50 oncogenes and tumour suppres...
Source: Journal of Molecular Diagnostics - Category: Pathology Authors: Source Type: research
Minimal-access myomectomy is overall considered as gold standard in symptomatic fibroma [1]. In order to continuously reduce invasiveness for patient care and at the same time avoiding the arisen morcellation problem, new transabdominal laparoscopic and transcervical hysteroscopic treatment options have emerged.
Source: The Journal of Minimally Invasive Gynecology - Category: OBGYN Authors: Tags: Letter to the Editor Source Type: research
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