MRI characteristics predict the efficacy of meloxicam treatment in patients with desmoid ‐type fibromatosis

This study aimed to determine the clinical significance of MRI characteristics as a possible predictor of responsiveness to meloxicam treatment in patients with desmoid ‐type fibromatosis (DF). Additionally, it analysed the correlation between CTNNB1 mutation status and signal intensity of MRI.MethodsForty ‐six patients consecutively treated with meloxicam composed this study. The low‐intensity area (LIA) on T2‐weighted MRI was determined. We divided patients into two groups based on the efficacy of meloxicam: a clinical benefit group (CB group, including CR: complete response; PR: partial respo nse; and SD: stable disease) and non‐clinical benefit group (NB group, including PD: progressive disease). Correlations of the efficacy with LIA and CTNNB1 mutation status with LIA were investigated.ResultsIn total, 11, 17 and 18 patients showed PR, SD and PD, respectively. The mean LIA ratio before treatment was significantly higher (P 
Source: Journal of Medical Imaging and Radiation Oncology - Category: Radiology Authors: Tags: Medical Imaging —Radiation Oncology—Original Article Source Type: research

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Publication date: October 2019Source: Journal of Comparative Pathology, Volume 172Author(s): M. Mikiewicz, K. Paździor-Czapula, M. Gesek, V. Lemishevskyi, I. Otrocka-DomagałaSummaryOral cavity tumours and tumour-like lesions are common in dogs and cats, and their diagnosis and classification requires histopathological examination. The aim of this study was to analyse retrospectively oral cavity lesions in dogs and cats in order to evaluate the distribution of inflammatory, hyperplastic and neoplastic lesions manifested as tumours. A total of 486 oral cavity tumours and tumour-like lesions (340 canine; 146 feline), diagno...
Source: Journal of Comparative Pathology - Category: Pathology Source Type: research
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Source: The Journal of Minimally Invasive Gynecology - Category: OBGYN Authors: Tags: Virtual Poster Session 2: Laparoscopy (1:00 PM – 1:10 PM) 1:00 PM: STATION F Source Type: research
Publication date: October 2019Source: Journal of Comparative Pathology, Volume 172Author(s): K. Pertl, M. Borchers, W. Baumgärtner, P. WohlseinSummaryA 2-year-old male Djungarian hamster (Phodopus sungorus) and a 1-year-old male Roborovski hamster (Phodopus roborovskii) were presented with expansile subcutaneous masses. The well-demarcated, firm, grey, multilobulated nodules displayed an homogeneous, white–grey cut surface. Histological examination revealed a neoplasm of variable cellularity consisting of spindle-shaped to polygonal ‘ganglion cell-like’ cells with abundant, amphophilic, vacuolated cy...
Source: Journal of Comparative Pathology - Category: Pathology Source Type: research
Publication date: Available online 8 October 2019Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): H. Lázare, A. Peteiro, M. Pérez Sayáns, P. Gándara-Vila, J. Caneiro, A. García-García, I. Antón, J.M. Gándara-Rey, J.M. Suárez-PeñarandaAbstractPeripheral ossifying fibromas are benign mesenchymal lesions that usually arise in the anterior maxilla of young female patients. Histologically they consist of spindle cell proliferation with focal mineralisation. We reviewed 48 specimens from 41 patients and recorded the clinical data, sex, and a...
Source: British Journal of Oral and Maxillofacial Surgery - Category: ENT & OMF Source Type: research
This report describes 2 clinical cases of middle-aged women with COF. Clinical examination revealed palatal mucosal depression; additionally, oral examination, as well as panoramic radiographs, intraoral radiographs, and computed tomography scans, revealed severe root resorption. This report highlights the clinical and radiological imaging features of COF, with the goal of enabling straightforward differential diagnosis of the lesion by the clinician and thereby appropriate treatment of the patient. PMID: 31583206 [PubMed]
Source: Imaging Science in Dentistry - Category: Dentistry Tags: Imaging Sci Dent Source Type: research
ConclusionIn the paediatric population, oral pathology shows an increasing tendency with age, with the majority of pathology being benign in nature comprising mainly of mucoceles and dental pathology particularly, periapical granuloma's and dentigerous cysts.
Source: Pediatric Dental Journal - Category: Dentistry Source Type: research
ConclusionsPatients affected by DTF experience psychological issues regarding the unpredictable tumour growth behaviour. Validation in a large international cohort is needed to devise a HRQL-questionnaire specific to DTF patients to fully address their needs.Legal entity responsible for the studyThe authors.FundingStichting Coolsingel Rotterdam.DisclosureAll authors have declared no conflicts of interest.
Source: Annals of Oncology - Category: Cancer & Oncology Source Type: research
This report illustrates a case of chondroblastic osteosarcoma in the region of anterior maxilla in a 58 ‐year‐old male patient previously treated for ossifying fibroma of the same site. Key Clinical MessageOsteosarcoma is the most common malignancy of mesenchymal cells mostly originating within long bones, but rarely in the jaws. This report illustrates a case of chondroblastic osteosarcoma in the region of anterior maxilla in a 58 ‐year‐old male patient previously treated for ossifying fibroma of the same site.
Source: Clinical Case Reports - Category: General Medicine Authors: Tags: CASE REPORT Source Type: research
We report the case of a patient with polyostotic fibrous dysplasia who had a giant mandibular lesion consisting of histologically typical, genotypically-confirmed, fibrous dysplasia merged with a fibrotic and hypocellular desmoplastic fibroma-like tissue in which the same Gsα-R201H mutation was detected. The occurrence of the same mutation in both the fibrous dysplasia and areas of desmoplastic fibroma suggests that the fibroma-like tissue reflects an unusual secondary tissue change within an otherwise typical fibrous dysplasia. To the best of our knowledge, only four cases of fibrous dysplasia with desmoplastic fibr...
Source: British Journal of Oral and Maxillofacial Surgery - Category: ENT & OMF Source Type: research
ConclusionsA 15-year-old Caucasian male was referred to the oral and maxillofacial radiology clinic for radiologic evaluation of a left posterior mandibular radiolucency. The patient complained of pain at the site. His medical and dental histories was positive for biopsy of multiple epidermoid cysts, a fibrous tissue mass on the lower back, and 2 odontomas. Thus far, the patient had not been identified to be at risk for Gardner syndrome. Panoramic and cone beam computed tomography (CBCT) radiographs were made and showed nonuniform hyperdensities throughout the jaws, impacted teeth, and a well-defined, multilocular, radiolu...
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research
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