Prolonged thromboprophylaxis with low molecular weight heparin for abdominal or pelvic surgery.

CONCLUSIONS: Prolonged thromboprophylaxis with LMWH significantly reduces the risk of VTE compared to thromboprophylaxis during hospital admittance only, without increasing bleeding complications or mortality after major abdominal or pelvic surgery. This finding also holds true for DVT alone, and for both proximal and symptomatic DVT. The quality of the evidence is moderate and provides moderate support for routine use of prolonged thromboprophylaxis. Given the low heterogeneity between studies and the consistent and moderate evidence of a decrease in risk for VTE, our findings suggest that additional studies may help refine the degree of risk reduction but would be unlikely to significantly influence these findings. This updated review provides additional evidence and supports the previous results reported in the 2009 review.
PMID: 31449321 [PubMed - as supplied by publisher]

Source: Cochrane Database of Systematic Reviews - August 25, 2019 Category: General Medicine Authors: Felder S, Rasmussen MS, King R, Sklow B, Kwaan M, Madoff R, Jensen C Tags: Cochrane Database Syst Rev Source Type: research