Risk factors and outcomes in non-transplant patients with extended-spectrum beta-lactamase-producing Escherichia coli bacteremia: a retrospective study from 2013 to 2016

ConclusionsPrior use of cephalosporin or BLBLI combination antibiotics increased the risk ratio forESBL-producingE. coli infection. Hypoproteinemia and severe disease are independent risk factors for death in patients withE. coli BSIs. There was no significant difference in the 28  day prognosis of patients with ESBL-producingE. coli and those with non-ESBL-producingE. coli BSIs. These data do not support the conclusion that carbapenems might be more effective than BLBLI antibiotics for treatment of patients with BSIs caused by ESBL-producingE. coli.
Source: Antimicrobial Resistance and Infection Control - Category: Infectious Diseases Source Type: research

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Conclusions: Due to high rates of resistance, strategies using empirical therapy of second-generation cephalosporins and fluoroquinolones should be reconsidered in this population. PMID: 31717981 [PubMed - in process]
Source: Medicina (Kaunas) - Category: Universities & Medical Training Authors: Tags: Medicina (Kaunas) Source Type: research
Abstract Urinary tract infections caused by the bacteria Escherichia coli are among the most frequently encountered infections and a common reason for antimicrobial prescriptions. Resistance to fluoroquinolone antimicrobials, and in particular ciprofloxacin, has increased in recent decades. It is intuitive that variation in resistance is driven by changes in antimicrobial use, but careful study of this association requires the use of time-series methods. We studied seasonal variation in ciprofloxacin, trimethoprim-sulfamethoxazole, and ampicillin resistance in community-acquired urinary E. coli isolates in Montrea...
Source: Am J Epidemiol - Category: Epidemiology Authors: Tags: Am J Epidemiol Source Type: research
ConclusionThese results provide knowledge of the phylogenetic relationships of E. coli from bacteraemia in Ecuadorian patients. ST131 has emerged in ESBL-Ec, representing an important public-health problem because this multiresistant clone is considered to be a vehicle for the propagation of antimicrobial resistance genes and is a highly virulent, well-adapted human pathogen.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
Conclusion: Elderly populations with diabetes are at a higher risk of UTI. Higher biofilm production and resistance to in-use antimicrobial agents in this study render its inefficacy for empirical treatment and point out the importance of biofilm screening to ensure the effective management of infection. PMID: 31641666 [PubMed - in process]
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
Authors: Bader MS, Loeb M, Leto D, Brooks AA Abstract Urinary tract infections (UTIs) caused by antibiotic- resistant Gram-negative bacteria are a growing concern due to limited treatment options. Knowledge of the common uropathogens in addition to local susceptibility patterns is essential in determining appropriate empiric antibiotic therapy of UTIs. The recommended first-line empiric antibiotic therapy for acute uncomplicated bacterial cystitis in otherwise healthy adult nonpregnant females is a 5-day course of nitrofurantion, a 3-g single dose of fosfomycin tromethamine, or a 5-day course of pevmecillinam. High...
Source: Postgraduate Medicine - Category: Internal Medicine Tags: Postgrad Med Source Type: research
ConclusionIt is concluded that NIT resistance in the studied NIT-RE. coli isolates was mainly mediated by nfsA and nfsB alterations.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
AbstractPurposeUrinary tract infections (UTI) are one of the most common reasons for prescribing antibiotics in primary care. In Switzerland, the Swiss Center for Antibiotic Resistances (ANRESIS) provides resistance data by passive surveillance, which overestimates the true resistance rates. The aim of this study was to provide actual data of the antimicrobial resistance patterns in patients with UTI in Swiss primary care.MethodsFrom June 2017 to August 2018, we conducted a cross-sectional study in 163 practices in Switzerland. We determined the resistance patterns of uropathogens in patients with a diagnosis of a lower UT...
Source: Infection - Category: Infectious Diseases Source Type: research
ConclusionsThe effectiveness of COL alone in vitro and in vivo suggested that intravenous CMS will be an effective and available therapeutic strategy for UTI due to MDR gram-negative pathogens. In-depth in vitro tests demonstrated that COL combined with DOR could be an attractive option, especially when COL MIC of the pathogen is ≥ 1 μg/ml.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
Microbial Drug Resistance, Ahead of Print.
Source: Microbial Drug Resistance - Category: Microbiology Authors: Source Type: research
Publication date: Available online 13 September 2019Source: Journal of Global Antimicrobial ResistanceAuthor(s): Vladimir Rafalskiy, Dmitry Pushkar, Sergey Yakovlev, Oleg Epstein, Mikhail Putilovskiy, Sergey Tarasov, Alexey Glazunov, Sergeiy Korenev, Ekaterina Moiseeva, Natalia GorelyshevaAbstractBackgroundUrinary tract infections (UTIs) are among the most common bacterial infections in clinical practice. The aim of the RESOURCE study was to determine the antimicrobial resistance profile of gram-negative bacteria isolated from outpatient urine samples collected across the Russian Federation.MethodsA total of 96,781 urine s...
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
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