1002 - looping and leukaemia: alterations in dna topology shape malignant transcriptional programmes

Cancer is initiated and maintained by malignant transcriptional programmes, with acute myeloid leukaemia (AML) an exemplar of this process. AML is associated with mutations in multiple transcriptional and epigenetic regulators and aberrant expression patterns in AML can be used to classify and provide prognostic and predictive data to personalise therapy and improve patient outcomes. However, while transcriptional outputs resulting from these lesions have been described in both model systems and patient samples, the mechanistic detail of how chromatin accessibility, chromatin activity and three dimensional DNA topology change in a coordinated manner to generate the aberrant transcriptional programmes that drive the leukaemia phenotype and how this is altered in a longitudinal fashion, is lacking.

Source: Experimental Hematology - July 31, 2019 Category: Hematology Authors: Brian Huntly Source Type: research