1005 - the identification of a peri-arteriolar niche for lymphoid progenitors and osteogenic progenitors in the bone marrow

Leptin Receptor-expressing (LepR+) stromal cells in adult bone marrow are highly enriched for skeletal stem cells and are the main source of osteoblasts and adipocytes in addition to SCF and Cxcl12 for HSC maintenance (Nature 481:457; Nature 495:231; Cell Stem Cell 15:154). We discovered that a subset of these cells produce a previously uncharacterized bone-forming growth factor, Clec11a/Osteolectin, which promotes the osteogenic differentiation of LepR+ cells and is required for the maintenance of adult skeletal bone mass (eLife 5:e18782).
Source: Experimental Hematology - Category: Hematology Authors: Source Type: research