1008 - changing neighbours: bone marrow remodelling during aging and age-related myeloproliferative disorders

Haematopoietic stem cells residing in the bone marrow accumulate during ageing but are functionally impaired. However, the role of haematopoietic-stem-cell-intrinsic and -extrinsic ageing mechanisms remains debated. Myeloid malignancies are more frequent in the elderly, but whether changes in the aged haematopoietic stem cells and/or their microenvironment predispose to these malignancies remains unclear. In the first part of the talk, unpublished evidence will be presented indicating that the bone marrow microenvironment promotes haematopoietic ageing, both during physiology and in premature, pathological haematopoietic ageing, which can be improved by targeting the microenvironment.
Source: Experimental Hematology - Category: Hematology Authors: Source Type: research