1009 - an ectoderm-derived myeloid-like cell population functions as antigen transporters for langerhans cells in zebrafish epidermis

In this study, we report the identification and characertization of a previously unappreciated myeloid-like cells population, which we refer to as metapgocytes, in zebrafish epidermis. We show that metaphocytes are of ectodermal origin and share a high degree of similarity with Langerhans cells in transcriptome, morphology and anatomic location. Remarkably, unlike Langerhans cells, metaphocytes respond to neither tissue injury nor bacterial infection, but rather sample soluble antigens from external enviroment through transepithelial protrusions and subsequently transfer the antigens to Langerhans cells via apoptosis-phagocytosis pathway.

Source: Experimental Hematology - July 31, 2019 Category: Hematology Authors: Zilong Wen, Xi Lin, Qiuxia Zhou, Changlong Zhao, Guanzhen Lin, Jin Xu Source Type: research