1015 - inhibition of endothelial mtor drives hematopoietic stem cell aging

Aging leads to a decline in hematopoietic stem cell (HSC) function. While some of these age-related changes reflect intrinsic alterations within HSCs, recent findings suggest that signals from the bone marrow (BM) microenvironment, in particular the BM vascular niche, might play a crucial role in regulating HSC aging. To this end, we recently discovered that aging of BM endothelial cells (BMECs) leads to an altered molecular crosstalk between the BMEC niche and HSCs that instructs young HSCs to behave as aged HSCs.
Source: Experimental Hematology - Category: Hematology Authors: Source Type: research