1019 - deconvolution of hematopoietic commitment decisions by genome-wide analysis of progressive dna methylation changes

Advances in single cell transcriptome analyses have resulted in the derivation of new models to describe the hierarchical organization of the mammalian hematopoietic system. While such an approach appears to be effective at discerning the trajectory of differentiation from hematopoietic stem cells (HSCs) to a given mature lineage, it remains a challenge to identify definitive points where specific lineage fates become restricted. 5-MeC is a stable epigenetic modification, whose remodeling is integral to the process of enforcing lineage-restricted gene expression programs.

Source: Experimental Hematology - July 31, 2019 Category: Hematology Authors: Michael Milsom Source Type: research