1021 - endothelial niche adhesive regulation of normal and malignant haematopoietic stem cells

Our laboratory previously identified a novel role for vascular cell adhesion molecules in promoting the awakening of dormant Haematopoietic Stem Cells (HSCs) in the bone marrow (BM) (Nat Med 2012). Now we show vascular niche adhesion can trigger a cascade of intracellular signalling events that can metabolically and transcriptionally reprogram a cell. For bone marrow (BM) Haematopoietic Stem and Progenitor Cells (HSPC) these open new avenues to tailor immune response and recovery during stress.Malignant cells also take advantage of these pathways.

Source: Experimental Hematology - July 31, 2019 Category: Hematology Authors: Ingrid Winkler Source Type: research