Hmg-xy regulates drug-resistance of acute myeloid leukemia cells through mapk pathway

Acute myeloid leukemia (AML) is a malignant, hyperproliferative neoplasm. Since its inception, chemotherapy and hematopoietic stem cell (HSC) transplantation have substantially improved the outcome of AML, but high rate of relapsed and refractory (R/R) AML remain the major obstacles in clinical treatment. As cholesterol metabolism supplies tumor cells with necessary intermediate products and greatly influences the pathogenesis and prognosis of AML. Cholesterol abnormal it, was found between AML CR and R/R patients, and HMGCS1, a critical gene acting in cholesterol synthesis, was supposed to contribute to this phenomenon.
Source: Experimental Hematology - Category: Hematology Authors: Tags: 3159 Source Type: research