Healthcare-Associated Infections in the Neurocritical Care Unit

This article summarizes updated data and knowledge on healthcare-associated infections in the neurocritical care unit, with a focus on central nervous system infections and systemic infectious complications in patients with acute brain disease. It also reviews the concept of brain injury-induced immune modulation, an underlying mechanism to explain why the neuro-ICU population is particularly susceptible to infections.Recent FindingsHealthcare-associated infections in the neuro-ICU are common: up to 40  % of meningitides in the developed world are now healthcare-associated. The number of gram-negative infections is rising. New diagnostic approaches attempt to aid in the diagnosis of healthcare-associated meningitis and ventriculitis.SummaryHealthcare-associated infections in the neurocritical care unit remain a challenge for diagnosis, treatment, and prevention. Gaining a better understanding of at-risk patients and development of preventative strategies will be the goal for future investigation.
Source: Current Neurology and Neuroscience Reports - Category: Neuroscience Source Type: research

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Conclusions: Identifying WNV infection early in its clinical course would help in decreasing inappropriate antibiotic use when patients presented with fever and meningeal symptoms. Performing WNV serology in CSF studies is critical in making the diagnosis. PMID: 32454831 [PubMed - as supplied by publisher]
Source: International Journal of Microbiology - Category: Microbiology Tags: Int J Microbiol Source Type: research
Neonatal bacterial meningitis remains a life-threatening and causative sequelae disease in newborns, despite the effective usage of antibiotics and improved critical medical care. Polymorphonuclear leukocyte (PMN) transendothelial migration across the blood-brain barrier, one of the three hallmarks of bacterial meningitis, now is considered as a “double-edge sword”. When participating in host immune system defending against virulent pathogens, it results in tissue inflammation and following severe damage of central nervous system at the same time, which contributes to a disastrous consequence. Recently, several...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
AbstractCoronavirus disease 2019 (COVID-19), a disease caused by the novel betacoronavirus (SARS-CoV-2), has become a global pandemic threat. The potential involvement of COVID-19 in central nervous system (CNS) has attracted considerable attention due to neurological manifestations presented throughout the disease process. In addition, SARS-CoV-2 is structurally similar to SARS-CoV, and both bind to the angiotensin-converting enzyme 2 (ACE2) receptor to enter human cells. Thus, cells expressing ACE2, such as neurons and glial cells may act as targets and are thus vulnerable to SARS-CoV-2 infection. Here, we have reviewed ...
Source: Journal of Neurology - Category: Neurology Source Type: research
Conclusion: The neurological manifestations associated with COVID-19 such as Encephalitis, Meningitis, acute cerebrovascular disease, and Guillain Barré Syndrome (GBS) are of great concern. But in the presence of life-threatening abnormal vitals in severely ill COVID-19 patients, these are not usually underscored. There is a need to diagnose these manifestations at the earliest to limit long term sequelae. Much research is needed to explore the role of SARS-CoV-2 in causing these neurological manifestations by isolating it either from cerebrospinal fluid or brain tissues of the deceased on autopsy. We also recommend...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Conclusion The findings indicated that nearly 30% of bilateral SNHL in Shandong province could be preventable through immunization, early prenatal diagnosis, proper treatment of infections, and avoidance of prescription of ototoxic drugs. This finding emphasizes the need for programs aimed at improving the health services at primary and secondary levels of health care, which will in turn prevent childhood hearing loss. PMID: 32437266 [PubMed - as supplied by publisher]
Source: American Journal of Audiology - Category: Audiology Authors: Tags: Am J Audiol Source Type: research
CONCLUSION: With the introduction of nusinersen treatment, neurologists and radiologists play an important role in treatment of SMA patients and therefore should be familiar with different techniques and complications of drug administration. Using good technique, it is possible to have very low complication rates even in this complex patient population, and various image-guided procedures can be a safe alternative to surgical approach, even in the most difficult cases. PMID: 32436843 [PubMed - as supplied by publisher]
Source: Diagnostic and Interventional Radiology : The Turkish Society of Radiology - Category: Radiology Authors: Tags: Diagn Interv Radiol Source Type: research
CONCLUSION: M. hominis was accepted as the causative agent of meningitis in this case report. PMID: 32419421 [PubMed - in process]
Source: The Turkish Journal of Pediatrics - Category: Pediatrics Authors: Tags: Turk J Pediatr Source Type: research
Publication date: Available online 18 May 2020Source: IDCasesAuthor(s): Ryan Mathern, Matthew Calestino
Source: IDCases - Category: Infectious Diseases Source Type: research
Higher education member Bill Acharjee (above) works at Solent University in Southampton as a research governance officer, with the task of ensuring that students and academics maintain ethical standards while they conduct their research projects. He’s thoughtful, conscientious. And while working from home during the COVID-19 crisis, he has a very sobering thought. “A world without universities would be tragic,” he says. “I just can’t comprehend it.” But there’s a very real danger some may struggle to survive, Mr Acharjee feels, if the government continues to refuse to come to the a...
Source: UNISON Health care news - Category: UK Health Authors: Tags: Article News coronavirus higher education Covid-19 Source Type: news
Bacterial meningitis is a serious inflammation of the meninges. Antimicrobial therapy on early cerebrospinal fluid (CSF) examination has an important role in diagnosis. The disease is still challenging in deve...
Source: BMC Microbiology - Category: Microbiology Authors: Tags: Research article Source Type: research
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