Host-Immune Interactions in JC Virus Reactivation and Development of Progressive Multifocal Leukoencephalopathy (PML)
AbstractWith the advent of immunomodulatory therapies and the HIV epidemic, the impact of JC Virus (JCV) on the public health system has grown significantly due to the increased incidence of Progressive Multifocal Leukoencephalopathy (PML). Currently, there are no pharmaceutical agents targeting JCV infection for the treatment and the prevention of viral reactivation leading to the development of PML. As JCV primarily reactivates in immunocompromised patients, it is proposed that the immune system (mainly the cellular-immunity component) plays a key role in the regulation of JCV to prevent productive infection and PML development. However, the exact mechanism of JCV immune regulation and reactivation is not well understood. Likewise, the impact of host factors on JCV regulation and reactivation is another understudied area. Here we discuss the current literature on host factor-mediated and immune factor-mediated regulation of JCV gene expression with the purpose of developing a model of the factors that are bypassed during JCV reactivation, and thus are potential targets for the development of therapeutic interventions to suppress PML initiation.Graphical Abstract
The House committee on health and the Senate commerce, consumer protection, and health committee will be holding an informational briefing on plans to combat the state's opioid epidemic with healthy alternatives on Thursday. Rep. John Mizuno, chair of the House committee on health, and Sen. Rosalyn Baker, chair of the Senate committee on commerce, consumer protection and health, are leading the meeting which will be held at 9 a.m. in room 329 of the Hawaii State Capitol. "Our goal is to better…
As China releases details about the 17 people who have died in the outbreak, a well-known SARS expert raises an alarm about the virus ’s spread, saying he feels “powerless.”
In sealing off a city of 11 million people, China is trying to halt a coronavirus outbreak using a tactic with a complicated history of ethical concerns.
The sudden restrictions — announced after the official death toll nearly doubled — could upend the travel plans of millions of Chinese citizens, who travel in huge numbers during the Lunar New Year holiday.
The former head of a drug company has been sentenced to two and a half years in federal prison in a bribery scheme that prosecutors say helped fuel the national opioid epidemic
Transport in Wuhan shut down and residents told not to leave centre of Sars-like epidemic
Epidemics of related viruses, like SARS, killed hundreds. Now the World Health Organization must decide whether to declare another global health emergency.
Beijing has responded faster to the new threat than it did with SARS, but it still silences and punishes those who veer from the official line, with potentially damaging consequences.
A senior health official warned that the annual Spring Festival holiday travel rush would complicate efforts to contain the outbreak, as the official death toll nearly doubled.
Yes. However, very probably not because of the novel coronavirus that has appeared in China. This seems to be front page headlines in every media outlet on the planet, and the World Health Organization has convened a meeting to decide whether to declare an official Global Health Emergency.This sort of flapdoodle happens every time a novel pathogen appears. Back when I lived in the Hub of the Universe a mosquito-borne disease called West Nile virus appeared (having formerly been large confined to, yes, west of the Nile). For weeks, every time a new case was identified it would be on the front page of the Boston Globe....