Infantile Hemangiomas: Daily Timolol Maleate Slows GrowthInfantile Hemangiomas: Daily Timolol Maleate Slows Growth

The gel formulation of a medicine approved in 1978 to treat glaucoma slows the growth of potentially disfiguring infantile hemangiomas with few of the adverse effects that limit other treatments. Medscape Medical News
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Pediatrics News Source Type: news

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Authors: Bejan-Angoulvant T, Angoulvant D Abstract Beta-blockers (BB) are an heterogenous set of molecules actively blocking β adrenergic receptors. Their pharmacological properties depend on their various effects on the adrenergic signalling. Although they are no longer a first-choice treatment in hypertensive patients, they remain a cornerstone of pharmacological strategy in several cardiovascular diseases such as stable angina, heart failure, arrythmia and aortic related connective diseases. Beyond their usual non cardiovascular indications such as migraine, hepatic cirrhosis, glaucoma, infantile hemangioma...
Source: Revue de Medecine Interne - Category: Internal Medicine Tags: Rev Med Interne Source Type: research
Conclusions: SWS affects approximately 0.19/100,000/year in Olmsted County. Early diagnosis, intervention, lifelong follow-up, and multidisciplinary approach should be used to optimize systemic and ocular outcomes. PMID: 32233696 [PubMed - as supplied by publisher]
Source: Ophthalmic Genetics - Category: Opthalmology Tags: Ophthalmic Genet Source Type: research
Authors: Karimi S, Arabi A, Shahraki T, Safi S Abstract Retinal hemangioblastoma (also referred to as retinal capillary hemangioma) is a benign lesion originating from the endothelial and glial components of the neurosensory retina and optic nerve head. Historically known as a manifestation of the von Hippel-Lindau (VHL) disease, it can be seen as an isolated finding or in association with some rare ocular conditions. In addition to characteristic ophthalmoscopic features, results of numerous ancillary tests including angiography, ultrasound, optical coherence tomography, and genetic tests may support the diagnosis...
Source: Journal of Ophthalmic and Vision Research - Category: Opthalmology Tags: J Ophthalmic Vis Res Source Type: research
PMID: 31433382 [PubMed - as supplied by publisher]
Source: Dermatitis - Category: Dermatology Authors: Tags: Dermatitis Source Type: research
Purpose of review Sturge–Weber syndrome (SWS) is a rare, congenital disease which frequently involves the eye. It is important that ophthalmologists recognize this syndrome and are aware of its range of ocular manifestations. The aim of this article is to present our understanding of the pathogenesis and clinical manifestations of this syndrome and provide updated information on the treatment of SWS glaucoma and choroidal hemangioma. Recent findings SWS glaucoma usually fails medical management. Surgical options include angle procedures, filtering procedures, device placement, and combination procedures. Combina...
Source: Current Opinion in Ophthalmology - Category: Opthalmology Tags: PEDIATRICS AND STRABISMUS: Edited by Cynthia Alley Source Type: research
Conclusions: To the best of our knowledge, this is the first observation of a secondary congenital glaucoma reversal with oral propranolol used for orbital IH management.
Source: Journal of Glaucoma - Category: Opthalmology Tags: Online Articles: Case Report/Small Case Series Source Type: research
Chronic wounds pose a major challenge on the health care system, with rising costs and associated morbidities. Better understanding of chronic wound biology and the advancement of technology have led to the use of an array of wound care therapies, including the off-label application of topical timolol for the healing of chronic wounds. Timolol is a non-selective, beta1/beta2 adrenergic receptor antagonist well established for the treatment of glaucoma. Clinical experience has broadened its use for a number of dermatologic indications such as infantile hemangiomas and recently chronic wounds.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Tissue Regeneration and Wound Healing Source Type: research
Ocular proton therapy (OPT) is considered the elective treatment for different kinds of highly malignant intraocular tumor. Uveal, iris and conjunctival melanomas, ocular hemangioma and retinoblastomas are amongst the lesions typically treated with OPT, particularly if target thickness prevents the applicability of other treatment modalities such as brachytherapy [1 –4]. A remarkable local control rate (well over 90%) was reported over the years by several institutions with over 28.000 patients treated worldwide [1,5,6], even though concomitant counter-effects, such as radiation induced damage to the lacrimal gland, ...
Source: Physica Medica: European Journal of Medical Physics - Category: General Medicine Authors: Tags: Original paper Source Type: research
A 12-year boy presented with decreased vision in the right eye. The uncorrected visual acuity was 6/12, which improved to 6/6 after myopic refractive correction. Examination revealed port-wine stain on the right side of the face and dilated episcleral blood vessels in the right eye suggestive of episcleral hemangioma (Figure 1A and B). Intraocular pressure was 26.0 and 14.0  mm Hg in the right and left eye respectively. There was a diffuse choroidal hemangioma, and the optic nerve head was cupped (cup-disc ratio 0.8), suggestive of glaucoma. The patient did not have any history of seizures, and MRI brain did not rev...
Source: QJM - Category: Internal Medicine Source Type: research
Sturge-Weber syndrome (SWS) is a sporadically occurring neurocutaneous syndrome characterized by port-wine stain over the face, ocular abnormalities (glaucoma and choroidal hemangioma), and leptomeningeal angiomas. It is usually diagnosed in infancy, but it may occasionally present in adulthood with seizures or stroke-like episodes. Here, we report a 46-year-old male patient, having SWS coexisting with moyamoya disease, attending our hospital due to sudden loss of consciousness. We also searched PubMed (from its earliest date to August 2014) for case reports mentioning that SWS presents in adulthood. We identified 31 patie...
Source: The Neurologist - Category: Neurology Tags: Case Report/Case Series Source Type: research
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