General Anesthesia Not Linked to Raised Risk for Dementia

Title: General Anesthesia Not Linked to Raised Risk for DementiaCategory: Health NewsCreated: 5/1/2013 12:35:00 PMLast Editorial Review: 5/2/2013 12:00:00 AM
Source: MedicineNet Alzheimer - Category: Geriatrics Source Type: news

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Publication date: Available online 5 September 2019Source: Alzheimer's &DementiaAuthor(s): Juraj Sprung, Phillip J. Schulte, David S. Knopman, Michelle M. Mielke, Ronald C. Petersen, Toby N. Weingarten, David P. Martin, Andrew C. Hanson, Darrell R. Schroeder, David O. WarnerAbstractIntroductionOur aim was to examine whether surgery with regional anesthesia (RA) is associated with accelerated long-term cognitive decline comparable with that previously reported after general anesthesia (GA).MethodsLongitudinal cognitive function was analyzed in a cohort of 1819 older adults. Models assessed the rate of change in global a...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
Abstract Chronic cerebral hypoperfusion (CCH) is associated with cognitive decline in aging, Alzheimer's disease and vascular dementia. Neural oscillations and their interactions support brain communication and involve in cognitive function. Although arginine vasopressin (AVP) has been linked to spatial learning and memory, the effects of AVP on CCH in terms of the hippocampal neural network is unknown. Here we investigated the dynamics of neural oscillations in the hippocampus in a rat model of permanent bilateral carotid arteries occlusion (two-vessel occlusion, 2VO) under urethane-anesthesia. Hypertonic saline ...
Source: Brain Research Bulletin - Category: Neurology Authors: Tags: Brain Res Bull Source Type: research
In this study, C57BL/6 and Tau KO mice were used. For Tau KO mice, Western blot results of anti-Tau protein specific antibodies showed that Tau KO mice had no positive bands at 50–55 kDa (Tau protein position), while C57BL/6 mice normally expressed Tau protein (Figure 1).FIGURE 1Figure 1 Tau knockout (KO) mice did not express Tau protein.The C57BL/6 mice exhibited depressive behaviors, including anxiety, anhedonia, and depression-like after CUMS, and ketamine treatment alleviated their depressive behavior. Tau KO mice did not exhibit depressive behavior after CUMS. After treatment with ketamine at the same dose, ther...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
This study was carried out in accordance with the recommendations of the National Animal Care and Use Committee of the University of Buenos Aires (CICUAL). The protocol was approved by the CICUAL. Mice were kept under a 12-h light/dark cycle, with controlled temperature (23 ± 2°C) and humidity (40–60%) and had ad libitum access to food and water. To produce hTDP-43 transgenic lines, as described previously (Igaz et al., 2011), pronucleus of fertilized eggs from C57BL/6J × C3HeJ F1 matings were injected with a vector containing hTDP-43-WT cDNA. Monogenic tetO-TDP-WT12 mice wer...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
Docosahexaenoic Acid Increases the Potency of Soluble Epoxide Hydrolase Inhibitor in Alleviating Streptozotocin-Induced Alzheimer’s Disease-Like Complications of Diabetes Rohit Pardeshi1, Nityanand Bolshette2, Kundlik Gadhave3, Mohammad Arfeen4, Sahabuddin Ahmed4, Rohitash Jamwal5, Bruce D. Hammock6, Mangala Lahkar2 and Sumanta Kumar Goswami6* 1Department of Biotechnology, National Institute of Pharmaceutical Education and Research (NIPER), Gauhati Medical College and Hospital, Guwahati, India 2Institutional Level Biotech Hub (IBT Hub), Department of Biotechnology, National Institute of Pharmaceutical Educatio...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Apelin-13 Suppresses Neuroinflammation Against Cognitive Deficit in a Streptozotocin-Induced Rat Model of Alzheimer’s Disease Through Activation of BDNF-TrkB Signaling Pathway Huaiqing Luo1, Yang Xiang1, Xiangping Qu1, Huijun Liu1, Chi Liu1, Guangyi Li2, Li Han3*† and Xiaoqun Qin1*† 1Department of Physiology, School of Basic Medical Science, Central South University, Changsha, China 2Department of Anatomy, Histology and Embryology, Changsha Medical University, Changsha, China 3Department of Physiology, School of Basic Medical Science, Changsha Medical University, Changsha, China Alzheimer&rsq...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Marcia H. Ratner, Vidhya Kumaresan and David H. Farb* Laboratory of Molecular Neurobiology, Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA, United States Memory dysfunction is a symptomatic feature of many neurologic and neuropsychiatric disorders; however, the basic underlying mechanisms of memory and altered states of circuitry function associated with disorders of memory remain a vast unexplored territory. The initial discovery of endogenous neurosteroids triggered a quest to elucidate their role as neuromodulators in normal and diseased brain functio...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
This study examined the effects of chronic administration of the 5-HT6R antagonist, SB-258585, on cognitive, memory, and hippocampal plasticity in a rat model of AD. Abeta neurotoxicity was induced in rats using Aβ (1.35 pmol intracerebroventricular [ICV] injection). The following groups were formed: control sustained surgery and saline-treated, Aβ+saline (1 μL ICV for 30 days), and Aβ+SB-258585 (0.024 mg/kg, ICV for 30 days). The learning and memory were tested using the novel object recognition and passive avoidance tests. Next, anesthetized rats were placed in a stereotaxic apparat...
Source: Behavioural Brain Research - Category: Neurology Authors: Tags: Behav Brain Res Source Type: research
To the Editor We read the article by Sieber et al with great interest. Postoperative delirium (PD) is an increasing problem and one of the least well-understood problems today. Whether general anesthesia leads to PD that in turn leads to or unmasks dementia (Alzheimer disease) is the bigger question, as referred to in the Editorial accompanying this article. Sieber et al hereby fail to prospectively find an association of PD with depth of anesthesia. Within its limitations, on the one hand, this reassures us of the safety of use of anesthetics in older patients; on the other hand, this once again reinforces our belief that...
Source: JAMA Surgery - Category: Sports Medicine Source Type: research
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