Hemoglobin S and glucose-6-phosphate dehydrogenase deficiency coinheritance in AS and SS individuals in malaria-endemic region: A study in Calabar, Nigeria

Conclusion: The result of this study supports the hypothesis that inheriting the G6PD deficiency gene and sickle cell gene (both in homozygous and heterozygous form) reduces the severity of malaria parasite infection and hence protects against severe acute malaria while having less effect on infection.
Source: Journal of Global Infectious Diseases - Category: Infectious Diseases Authors: Source Type: research

Related Links:

Publication date: Available online 18 November 2019Source: Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular BiologyAuthor(s): V. Šustr, S. Semanová, M.M. Rost-Roszkowska, K. Tajovský, A. Sosinka, F. KaszubaAbstractMillipedes represent a model for the study of organic matter transformation, animal-microbial interactions, and compartmentalisation of digestion. The activity of saccharidases (amylase, laminarinase, cellulase, xylanase, chitinase, maltase, cellobiase, and trehalase) and protease were measured in the midgut and hindgut contents and walls of the millipedes Archispiro...
Source: Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology - Category: Molecular Biology Source Type: research
Publication date: Available online 18 November 2019Source: Fish &Shellfish ImmunologyAuthor(s): Rongrong Ma, Youbin Yu, Xiao Liu, Yuhua Lei, Suming Zhou, Xiao Xie, Shan Jin, Dong Qian, Fei YinAbstractMassive infection caused by Cryptocaryon irritans is detrimental to the development of marine aquaculture. Recently, our lab found that Nibea albiflora has low sensitivity and low mortality to C. irritans infection. The present study was designed to investigate the mechanisms of the N. albiflora response to C. irritans infection by analyzing transcriptome changes in the skin. Skin samples of control and experimental groups...
Source: Fish and Shellfish Immunology - Category: Biology Source Type: research
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Conclusion: People with obesity who incur an SCI need special attention to prevent early mortality. Future studies should explore factors that contribute to such a higher mortality after SCI, such as preexisting conditions and comorbidities. The effects of BMI on long-term mortality also deserve further investigation. PMID: 31729925 [PubMed - as supplied by publisher]
Source: Journal of Spinal Cord Medicine - Category: Orthopaedics Tags: J Spinal Cord Med Source Type: research
Abstract The microsporidium Nosema sp. SE is a pathogen that infects the beet armyworm Spodoptera exigua. The complete sequence of its 4,302-base pair (bp) ribosomal ribonucleic acid (rRNA) gene region was obtained by polymerase chain reaction amplification and sequencing. The rRNA organization of Nosema sp. SE was 5'-large subunit (LSU) rRNA-internal transcribed spacer-small subunit (SSU) rRNA-intergenic spacer-5S-3', which corresponded to the pattern of Nosema bombycis. Phylogenetic analysis based on LSU rRNA and SSU rRNA both indicated that the parasite had a close relationship with other true Nosema species, c...
Source: The Journal of Parasitology - Category: Parasitology Authors: Tags: J Parasitol Source Type: research
Abstract Knowledge of helminth life cycles is essential to understanding their host specificity, geographic distribution, and transmission. Many helminth life cycle descriptions are based on field collections in a limited part of the parasite's range. However, it is important to determine whether helminth life cycles and host specificity remain consistent across their geographic range so that we may better understand their life history and transmission ecology. Here, we investigated whether the life cycle of a widespread trematode, Quinqueserialis quinqueserialis (Notocotylidae) varies across its geographic range....
Source: The Journal of Parasitology - Category: Parasitology Authors: Tags: J Parasitol Source Type: research
A school project on traditional soups illustrates the mysterious world of science and how solutions might be found in ancient ways.
Source: CNN.com - Health - Category: Consumer Health News Source Type: news
AbstractWhile searching for novel anti-echinococcosis drugs, we have been focusing on glycolysis which is relied on byEchinococcus for energy production and intermediates for other metabolic processes. The aim of this study was to investigate the potential therapeutic implication of glycolytic inhibitors onEchinococcus. Our results demonstrate that at an initial concentration of 40  μM, all inhibitors of glycolysis used in the current experiment [3-bromopyruvate (3-BrPA), ornidazole, clorsulon (CLS), sodium oxamate and 2,6-dihydroxynaphthalene (NA-P2)] show considerable in vitro effects againstEchinococcus granulos...
Source: Veterinary Research - Category: Veterinary Research Source Type: research
A Dalit woman stands outside a dry toilet located in an upper caste villager’s home in Mainpuri, in the northern Indian state of Uttar Pradesh. Credit: Shai Venkatraman/IPSBy External SourceUNITED NATIONS, Nov 18 2019 (IPS) Ending the practice of defecating in the open, rather than in a toilet, will have “transformational benefits” for some of the world’s most vulnerable people, says the UN’s partner sanitation body, the WSSCC (Water Supply and Sanitation Collaborative Council). Ahead of World Toilet Day, which is marked annually on 19 November, WSSCC’s acting Executive Director, Sue Co...
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Development & Aid Global Headlines Health Water & Sanitation Source Type: news
LITFL • Life in the Fast Lane Medical Blog LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog aka Tropical Travel Trouble 007 When you think tropical medicine, malaria has to be near the top. It can be fairly complex and fortunately treatment has become a lot simpler. This post is designed to walk you through the basic principals with links to more in depth teaching if your niche is travel medicine, laboratory diagnostics or management of severe or cerebral malaria. If you stubbled on this post while drinking a cup of tea or sitting on the throne and want a fe...
Source: Life in the Fast Lane - Category: Emergency Medicine Authors: Tags: Clinical Cases Tropical Medicine malaria Plasmodium plasmodium falciparum plasmodium knowles plasmodium malariae plasmodium ovale plasmodium vivax Source Type: blogs
More News: Endemics | G6PD | Genetics | Infectious Diseases | Malaria | Nigeria Health | Parasitic Diseases | Parasitology | Sickle Cell Anemia | Study | Teaching | Teaching Hospitals | Universities & Medical Training