Differentiated treatment strategies for bone metastases of the extremities.

[Differentiated treatment strategies for bone metastases of the extremities]. Orthopade. 2019 Aug 23;: Authors: Rath B, Tingart M, Migliorini F, Eschweiler J, Zureik R, Hardes J Abstract BACKGROUND: Bone metastases are the most common malignant bone tumours and most commonly occur in the spine, pelvis, proximal femur and proximal humerus. Prostate and breast cancer most often metastasize to the bone. DIAGNOSTICS: In patients with a history of tumours and local unspecific pain in the back and extremities, further diagnostic examinations should be performed. For the initial diagnosis a conventional radiograph of the whole bone in two planes is sufficient. For further diagnostics, the imaging may be supplemented with CT, MRI, scintigraphy and a PET-CT (PET-MRI) if the findings are not inconspicuous on the x‑ray. An indication for biopsy exists if the tumor cannot be classified, especially in solitary findings with or without previous tumor anamnesis. THERAPY: Surgical indications for bone metastases are a pathological fracture, an impending fracture, a solitary late metastasis, radiation-resistant osteolysis and therapy-resistant pain. In solitary metastases, the prognosis for patients can be significantly improved by a wide (R0 resection) depending on the primary tumour. For multiple metastases the restoration of mobility and improvement of the quality of life are in the foreground. Depending on the life expec...
Source: Der Orthopade - Category: Orthopaedics Authors: Tags: Orthopade Source Type: research

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The headline in a main Finnish newspaper on 16 November announced: “Trust and interest for published science has increased in Finland”. I would have hypothesized that evidence-based knowledge was losing the game against the rush of non-scientific and commercial information – but I was wrong. A 3-year follow-up survey among the Finland population was clear on this. Could the growth in electronic and social media information actually be causing people to search for knowledge based on scientific facts? Forty-five years have passed since the publication of the first issue of the Scandinavian Journal of Work...
Source: Scandinavian Journal of Work, Environment and Health - Category: Occupational Health Tags: Editorial Source Type: research
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Source: The Medical Futurist - Category: Information Technology Authors: Tags: Future of Medicine Personalized Medicine cancer digital health cancer treatment digital technology oncology cancer research cancer care digital health technologies Source Type: blogs
Conditions:   Anesthesia;   Analgesia;   Acute Pain;   Chronic Pain;   Pectoralis Nerve Block;   Erector Spine Plane Block;   Patient Controlled Analgesia Interventions:   Procedure: Pectoralis nerve block;   Procedure: Erector spine plane block;   Other: Control Sponsors:   Ondokuz Mayıs University;   CENGİZ KAYA (ckaya) Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
TIME held its first TIME 100 Health Summit on Thursday aiming to define — and shape — the future of health care. The Summit, which is an offshoot of the magazine’s annual TIME 100 list of influential people, featured scientists, politicians and entertainers, such as former President Bill Clinton, former Vice President Al Gore, NIH Director Dr. Francis Collins, actress Selma Blair, NBA commissioner Adam Silver, comedian Tig Notaro and former Planned Parenthood President Dr. Leana Wen. The day included a range of interviews, panels and performances. Here are the biggest moments from the Summit. Former Vice ...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Comedy HealthSummit19 onetime Source Type: news
This study tested the hypothesis that vascular endothelial growth factor A and vascular endothelial growth factor receptor 2 contribute to bone cancer pain regulation associated with spinal central sensitization.Methods This study was performed on female rats using a metastatic breast cancer bone pain model. Nociceptive behaviors were evaluated by mechanical allodynia, thermal hyperalgesia, spontaneous pain, and CatWalk gait analysis. Expression levels were measured by real-time quantitative polymerase chain reaction, western blot, and immunofluorescence analysis. Excitatory synaptic transmission was detected by whole-cell...
Source: Anesthesiology - Category: Anesthesiology Source Type: research
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Source: The Neurocritic - Category: Neuroscience Authors: Source Type: blogs
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Source: Clinical Nuclear Medicine - Category: Nuclear Medicine Tags: Interesting Images Source Type: research
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Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research
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Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
This article is protected by copyright. All rights reserved. PMID: 31429474 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Pharmacology and Physiology - Category: Drugs & Pharmacology Authors: Tags: Clin Exp Pharmacol Physiol Source Type: research
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