Prescription omega-3s can help some heart patients
For people with very high triglycerides, doctors generally recommend exercise and dietary changes, and if that doesn't work, statins, fibrates or niacin. But a new advisory from the American Heart Association says that prescription omega-3 fatty acids can help reduce very high trigylceride levels by 20 to 30%, and the medications can be used safely in conjunction with statins.
Clinical Liver Disease, Volume 15, Issue 2, Page 69-70, February 2020.
Hwang Statins such as simvastatin have many side effects, including muscle damage, which is known to be the most frequent undesirable side effect. Lysophosphatidic acid (LPA), a kind of biolipid, has diverse cellular activities, including cell proliferation, survival, and migration. However, whether LPA affects statin-linked muscle damage has not been reported yet. In the present study, to determine whether LPA might exert potential protective effect on statin-induced myocyotoxicity, the effect of LPA on cytotoxicity in rat L6 myoblasts exposed to simvastatin was explored. Viability and apoptosis of rat L6 myoblasts we...
In conclusion, berberine-induced nuclear translocation of FXR and LXRα could activate OATP1B1 promoter, resulting in enhanced expression of OATP1B1 and increased uptake of rosuvastatin.
Risk for heart failure hospital visit declined with statins for women receiving anthracyclines, trastuzumab
Condition: Diabetes Intervention: Sponsor: University Hospital, Montpellier Active, not recruiting
Authors: Hermans MP, Ahn SA, Rousseau MF Abstract Background: New recommendations call for lowering LDL-C
Abstract Diabetes mellitus (DM) is one of the most common diseases in the world. Among its effects are an increase in the risk of cognitive impairment, including Alzheimer's disease, and blood-brain barrier (BBB) dysfunction. DM is characterized by high blood glucose levels that are caused by either lack of insulin (Type I) or resistance to the actions of insulin (Type II). The phenotypes of these two types are dramatically different, with Type I animals being thin, with low levels of leptin as well as insulin, whereas Type II animals are often obese with high levels of both leptin and insulin. The best characteri...
Conditions: Venous Thromboembolism; Blood Clot; Post Thrombotic Syndrome Interventions: Drug: Rosuvastatin Calcium; Drug: Placebo Oral Tablet Sponsor: Ottawa Hospital Research Institute Not yet recruiting
To outline the challenges and provide practical recommendations for recruiting inactive, statin-free older adults to facilitate feasible study designs. Data was obtained from a double-blind randomised-controll...
CONCLUSIONS: A Statin and RASI combination therapy significantly reduced the cumulative incidence of MACEs compared with a monotherapy of these drugs. Moreover, the combination therapy showed a reduced all-cause death rate compared with statin monotherapy, and a decreased repeat revascularization rate compared with RASI monotherapy. PMID: 32207841 [PubMed - as supplied by publisher]