Synthesis, molecular structure, anti-microbial, anti-oxidant and enzyme inhibition activities of 2-amino-6-methylbenzothiazole and its Cu(II) and Ag(I) complexes

Publication date: 5 January 2020Source: Journal of Molecular Structure, Volume 1199Author(s): Zarif Gul, Niqab Ud Din, Ezzat Khan, Farhat Ullah, Muhammad Nawaz TahirAbstractMolecular structure of 2-amin-6-methylbenzothiazole, 1 and its coordination complexes with Ag(I) and Cu(II) were determined by X-ray diffraction. The ligand 2-amin-6-methylbenzothiazole (hereafter represented as L in general formula of complexes) and [AgL2]NO3 crystallize in orthorhombic crystal systems and CuL2(OAc)2 complex is monoclinic. Ligand and its Ag(I) complex possess space groups Pbcn and Cu(II) complex has a space group P21/c. Complex bis(2-amino-6-methylbenzothiazole)diacetatocopper(II), 2 and bis(2-amino-6-methylbenzothiazole)silver(I) nitrate, 3 were obtained by reacting ligand with respective metal salt in a molar ratio 2:1, respectively. The coordination environment of copper metal is octahedral where acetate acts as bidentate ligand and 2-amino-6-methylbenzothiazole occupies trans position with respect to each other. The ligand contains three possible coordination sites (endocyclic nitrogen, exocyclic nitrogen and sulphur). Among three nucleophilic centers the endocyclic nitrogen is more basic and readily coordinates to the metal ion (both Cu and Ag). Nitrate group plays an important role in stabilizing the supramolecular structure of Ag complex wherein NO…H2N- interactions are very effective. Non-covalent interactions in molecules make them efficient medicines. On the basis of certain s...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research