Commentary on “Disruption of Neural Homeostasis as a Model of Relapse and Recurrence in Late-Life Depression”

Global burden of disease 2010 ranked major depressive disorder as a leading worldwide contributor to years of life lived with disability.1 Between 1990 and 2010 depression's contribution to global disability increased substantially due to population growth and notably to aging. Late-life depression (LLD) is now a major public health concern with nearly 5 million sufferers in America alone. LLD also heightens the risk for medical comorbidities, cognitive decline, poor quality of life, caregiver burden, premature mortality and suicides.
Source: The American Journal of Geriatric Psychiatry - Category: Geriatrics Authors: Tags: Invited Perspective Source Type: research

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Late-life depression (LLD) is associated with significant public health burden, high disability, increased risk for cognitive decline and dementia, elevated suicide risk, and greater all-cause mortality rates.1 These negative outcomes are magnified by depression being a recurrent disorder, characterized by repeated episodes over a patient's lifetime.
Source: The American Journal of Geriatric Psychiatry - Category: Geriatrics Authors: Tags: Clinical Review Article Source Type: research
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