Synthesis and fungicidal activity of novel pyrazole derivatives containing 5-Phenyl-2-Furan.

Synthesis and fungicidal activity of novel pyrazole derivatives containing 5-Phenyl-2-Furan.
Bioorg Med Chem. 2019 Aug 16;:115048
Authors: Ahmed W, Yan X, Hu D, Adnan M, Tang RY, Cui ZN
Abstract
Pyrazole constitutes an important heterocyclic family covering a broad range of synthetic as well as natural products that exhibit numerous chemical, biological, agrochemical and pharmacological properties. In order to explore compounds with good fungicidal activity, a series of new pyrazole derivatives containing 5-phenyl-2-furan were designed and synthesized. In vitro and in vivo fungicidal activities were evaluated and the compound ethyl-1-(5-phenylfuran-2-carbonyl)-5-propyl-1H-pyrazole-3-carboxylate (I8) displayed significant fungicidal activity against various fungi, especially against P. infestans. The structures of the novel pyrazole derivatives were confirmed by 1H NMR, 13C NMR, MS, elemental analysis and X-ray single crystal diffraction. Further study showed that compound I8 might act on the synthesis of cell walls from morphological and ultrastructural studies by SEM and TEM. The results also revealed that compound I8 could block the nutritional transportation leading to cells senescence and death. These results suggested that the novel pyrazole derivatives proved to be promising lead compounds.
PMID: 31439387 [PubMed - as supplied by publisher]

Source: Bioorganic and Medicinal Chemistry - August 15, 2019 Category: Chemistry Authors: Ahmed W, Yan X, Hu D, Adnan M, Tang RY, Cui ZN Tags: Bioorg Med Chem Source Type: research