Left bundle branch block-induced cardiomyopathy: Myth or reality?

Left bundle branch block (LBBB) is a frequent finding in heart failure population, especially in patients with dilated cardiomyopathy (DCM). Traditionally, LBBB was considered rather as a consequence than as a cause of the myocardial disease. This assumption was reinforced by the fact LBBB is associated with poor prognosis. However, the observation of “hyper-responders” to cardiac resynchronization therapy (CRT) among patients with DCM and LBBB, have contributed to the emergence of the entity of LBBB-induced DCM [1].
Source: International Journal of Cardiology - Category: Cardiology Authors: Tags: Editorial Source Type: research

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ConclusionsSARM predicts non ‐response to CRT and may help in the selection of CRT candidates.This article is protected by copyright. All rights reserved
Source: Pacing and Clinical Electrophysiology : PACE - Category: Cardiology Authors: Tags: DEVICES Source Type: research
Conclusions: The clinical course of patients with ICM and DCM treated with CRT-D differs significantly during long-term follow-up, with increased mortality and incidence of ICD therapies in ICM patients. PMID: 31360179 [PubMed]
Source: Archives of Medical Science - Category: General Medicine Tags: Arch Med Sci Source Type: research
Yolanda Benito1, Pablo Martinez-Legazpi1*, Lorenzo Rossini2, Candelas Pérez del Villar1, Raquel Yotti1, Yolanda Martín Peinador3, Daniel Rodríguez-Pérez4, M. Mar Desco4, Constancio Medrano1, Jose Carlos Antoranz4, Francisco Fernández-Avilés1, Juan C. del Álamo2,5 and Javier Bermejo1 1Department of Cardiology, Hospital General Universitario Gregorio Marañón, Facultad de Medicina, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria Gregorio Marañón and CIBERCV, Madrid, Spain 2Department of Mechanical and Aerospace ...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Investigations in dilated cardiomyopathy Chest X-ray PA view will assess the cardiac size in dilated cardiomyopathy and show evidence of pulmonary congestion. Sick persons may present with features of frank pulmonary edema in the form of hilar haze or bat wing pattern of pulmonary edema. Significant left ventricular dysfunction can exist without much of cardiomegaly on chest X-ray as well. ECG may show sinus tachycardia, left atrial overload and sometimes left ventricular hypertrophy. A wide QRS complex with left bundle branch block pattern may indicate potential benefit from cardiac resynchronization therapy (CRT). ECG ...
Source: Cardiophile MD - Category: Cardiology Authors: Tags: General Cardiology Source Type: blogs
Abstract BACKGROUND: The treatment of heart failure has changed with the use of angiotensin-converting enzyme inhibitors (ACEIs) and beta-blockers since the middle of the 1990s. However, the outcome in infantile dilated cardiomyopathy (DCM) when treated with them remains poorly understood. METHODS: We reviewed the medical records of infants with DCM within 24 months old in our hospital between 1979 and 2012, and compared the outcome in the later group (1997-2012) with that in the early group (1979-1996). The survival and cardiac event (CE)-free survival rates were calculated by the Kaplan-Meier method. R...
Source: Journal of Cardiology - Category: Cardiology Authors: Tags: J Cardiol Source Type: research
ConclusionsShorter time from onset of QRS to beginning of fragmentation is a simple ECG marker to predict non-responsive patients to CRT.ResumenObjetivoLa terapia de resincronización cardíaca (TRC) es una opción eficaz en el tratamiento de los pacientes con insuficiencia cardíaca y QRS ancho. Se ha demostrado que la presencia de un QRS fragmentado (QRS-f) en el electrocardiograma (ECG) de 12 derivaciones se asocia con una no respuesta a la TRC. El objetivo de este estudio es valorar si la aparición de la fragmentación (intervalo Q-f) es importante en la respuesta a la TRC.Mé...
Source: Revista Clinica Espanola - Category: Internal Medicine Source Type: research
Publication date: Available online 8 February 2019Source: Revista Portuguesa de Cardiologia (English Edition)Author(s): Daniel Bonhorst, Sara Guerreiro, Cândida Fonseca, Nuno Cardim, Filipe Macedo, Pedro AdragãoAbstractIntroductionThe aim of this study was to document clinical practice in Portugal regarding the use of electronic cardiac devices in patients with heart failure (HF) and reduced left ventricular ejection fraction (LVEF).MethodsThe Síncrone study was an observational prospective multicenter registry conducted in 16 centers in Portugal between 2006 and 2014. It included adult patients with a ...
Source: Revista Portuguesa de Cardiologia - Category: Cardiology Source Type: research
Dilated cardiomyopathy (DCM) is the commonest cause of heart failure and cardiac transplantation worldwide [1]. Morbidity and mortality in DCM has improved considerably with optimal medical therapy (OMT), identification of affected individuals at earlier stages of the disease process, and by the use of implantable cardioverter defibrillators (ICD) and cardiac resynchronization therapy (CRT).
Source: International Journal of Cardiology - Category: Cardiology Authors: Tags: Editorial Source Type: research
In conclusion, CRT provides beneficial effects in terms of clinical status and left ventricular function on IVNC patients with heart failure. CRT responders seem to have a great left ventricular reverse remodeling supporting the theory that CRT is able to provide an additional benefit in the IVNC disease, improving the performance of IVNC segments, when paced.
Source: Journal of Cardiovascular Medicine - Category: Cardiology Tags: Reviews Source Type: research
We present a case of 71-year-old woman with dilated cardiomyopathy, NYHA functional class III and AF. We implanted CRT combined with direct His-bundle pacing. The indication for such a therapy was a left bundle branch block with a QRS complex of 178ms and a left ventricular EF of 15%, left ventricular end-diastolic diameter (LVEDD) of 75mm. After 8months of follow-up the LVEDD was 60mm with EF 35 –40%.
Source: Journal of Electrocardiology - Category: Cardiology Authors: Source Type: research
More News: Cardiac Resynchronization Therapy | Cardiology | Cardiomyopathy | Dilated Cardiomyopathy | Heart | Heart Failure