A case of invasive mucinous adenocarcinoma of the lung showing stepwise progression at the primary site

Invasive mucinous adenocarcinoma (IMA) is a variant of lung adenocarcinoma [1]. The tumor cells in IMA are columnar and contain abundant intracytoplasmic mucin, mimicking goblet cells of the colon [1]. IMA is often positive for HNF4-alpha, but negative for TTF-1 [1]. IMA reveals genetic abnormalities similar to those of colorectal carcinoma and commonly shows KRAS mutation (in up to 90% of cases) [1,2].

Source: Lung Cancer - August 23, 2019 Category: Cancer & Oncology Authors: Hitomi Kawai, Masato Sugano, Noriyuki Nakano, Masafumi Muratani, Shingo Sakashita, Yukinobu Goto, Masayuki Noguchi Source Type: research