Synthesis, structural characterization and anti-breast cancer activity evaluation of three new Schiff base metal (II) complexes and their nanoparticles
Publication date: 5 January 2020Source: Journal of Molecular Structure, Volume 1199Author(s): Di Wu, Liang Guo, Si-Jie LiAbstractTwo Schiff base ligands 2-((ethylamino)methyl)-6-methoxyphenol (HL1) and (E)-2-(((2-(dimethylamino)ethyl)imino)methyl)-6-methoxyphenol (HL2) with bi-nucleating or tri-nucleating mode have been successfully prepared via an one step organic condensation reaction, which were further applied in the synthesis of three new Cu(II) and Ni(II)-based coordination complexes [Cu(L1)2](EtOH) (1), [Ni(L1)2](EtOH) (2) and [Cu(L2)(HL2)(SCN)](MeOH)2 (3). Furthermore, a hand grinding technique has been used to decrease the particle diameter of complexes 1–3, thus forming nano-complexes. In biological activity research, we revealed the important function of nanoparticle 1 in the treatment of breast cancer. Mitochondria is critical in generating intracellular energy, and play a vital role in regulating cells life and death. Therefore, the apoptosis of MCF7 breast cancer cells after treated with nanoparticles was detected by Annexin V-FITC/PI method. The results showed that nanoparticles 1 could significantly raise apoptotic cells number, but not nanoparticles 2–3. Moreover, we assessed the mitochondrial membrane potential and reactive oxygen species (ROS) in MCF7 cancer cells, finally we draw this conclusion, nanoparticle 1 could damage the mitochondrial membrane, leading increased ROS level, and cause the apoptotic cell death.
A causal link between Human Papillomavirus (HPV) and breast cancer (BC) remains controversial. In spite of this, the observation that HPV DNA is over-represented in the Triple Negative (TN) BC has been reported. Here we remark the high prevalence of HPV DNA (44.4%) in aggressive BC subtypes (TN and HER2+) in a population of 273 Italian women and we convey the presence of HPV DNA in the epithelial and stromal compartments by in situ hybridization. As previously reported, we also found that serum derived-extracellular vesicles (EVs) from BC affected patients contain HPV DNA. Interestingly, in one TNBC patient, the same HPV D...
Cell Death &Differentiation, Published online: 17 September 2019; doi:10.1038/s41418-019-0419-1Deubiquitylation and stabilization of Notch1 intracellular domain by ubiquitin-specific protease 8 enhance tumorigenesis in breast cancer
British Journal of Cancer, Published online: 17 September 2019; doi:10.1038/s41416-019-0576-5Comment on: “Preventing chemotherapy-induced alopecia: a prospective clinical trial on the efficacy and safety of a scalp-cooling system in early breast cancer patients treated with anthracyclines”
British Journal of Cancer, Published online: 17 September 2019; doi:10.1038/s41416-019-0577-4Reply to Comments on: “Preventing chemotherapy-induced alopecia: a prospective clinical trial on the efficacy and safety of a scalp cooling system in early breast cancer patients treated with anthracyclines.”
Breast cancer and Childhood cancerFor more information go tohttps://www.cancer.gov/grants-training/training/resources-trainees/courses-fellowships/translational-research-clinical oncologyAir date: 10/21/2019 4:00:00 PM
Whole- and partial-breast radiation after lumpectomy produce similar cosmetic...Read more on AuntMinnie.comRelated Reading: ASTRO: Weekly breast radiation therapy is safe ASTRO: Radiation therapy slashes breast cancer recurrence ASTRO releases new breast radiation therapy guideline Cancer: Breast radiation therapy isn't so bad Women not getting recommended breast radiation therapy
Condition: Breast Cancer Intervention: Dietary Supplement: VITAMIN D Sponsor: Institut du Cancer de Montpellier - Val d'Aurelle Completed
Conditions: Advanced Breast Carcinoma; Anatomic Stage III Breast Cancer AJCC v8; Anatomic Stage IIIA Breast Cancer AJCC v8; Anatomic Stage IIIB Breast Cancer AJCC v8; Anatomic Stage IIIC Breast Cancer AJCC v8; Anatomic Stage IV Breast Cancer AJCC v8; Germlin e BRCA1 Gene Mutation; Germline BRCA2 Gene Mutation; HER2/Neu Negative; Metastatic Breast Carcin...
Conditions: Anatomic Stage IV Breast Cancer AJCC v8; Breast Carcinoma Metastatic in the Bone; Metastatic Breast Carcinoma; Metastatic Triple-Negative Breast Carcinoma; Prognostic Stage IV Breast Cancer AJCC v8 Interventions: Drug: Paclitaxel; Radiation: Radium Ra 223 Dichloride Sponsor: National Cancer Institute (NCI) Not yet recruiting
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