Electrochemical sensitive determination of acetaminophen in pharmaceutical formulations at iron oxide/graphene composite modified electrode

Publication date: Available online 23 August 2019Source: Arabian Journal of ChemistryAuthor(s): Venkata Narayana Palakollu, Tirivashe E. Chiwunze, Chen Liu, Rajshekhar KarpoormathAbstractAcetaminophen (AC) is one of the most commonly prescribed analgesic and antipyretic drug, which is considered to be safe as well as effective. Rational use of AC does not pose any toxicity or adverse effects, however, an overdose or prolonged use could lead to nephrotoxicity and severe hepatoxicity. Thus, monitoring of AC is essential for drug safety. In this work, a facile Fe2O3/reduced graphene oxide (Fe2O3/RGO) nanocomposite was synthesized for improved electrochemical detection of acetaminophen (AC). The material was synthesized through a simple one-step process. For characterization of synthesized Fe2O3/RGO composite, energy-dispersive X-ray spectroscopy (EDX), field emission-scanning electron microscopy (FE-SEM) and electrochemical impedance spectroscopy (EIS) were employed. To verify the electrochemical performance of Fe2O3/RGO nanocomposite, GCE was modified with this nanocomposite and utilized for quantification of AC. The detection limit of AC was 21 nM in a linear range from 1.0×10-7 to 74×10-6 M. Furthermore, the sensor also unveiled good stability, promising sensitivity and selectivity. Hence, Fe2O3/RGO could be applied as a sensing material for electrochemical detection of AC. Finally, the analytical utility of the method was also verified in human urine and drug sam...
Source: Arabian Journal of Chemistry - Category: Chemistry Source Type: research

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Abstract Internal organ motion during radiation delivery may lead to underdosing of cancer cells or overdosing of normal tissue, potentially causing treatment failure or normal-tissue toxicity. Organ motion is of particular concern in the treatment of lung and abdominal cancers, where breathing induces large tumor displacement and organ deformation. A new generation of radiotherapy devices is equipped with on-board MRI scanners to acquire a real-time movie of the patient's anatomy during radiation delivery. The goal of this research is to develop, calibrate, and test motion predictive models that employ real-time ...
Source: Physics in Medicine and Biology - Category: Physics Authors: Tags: Phys Med Biol Source Type: research
ng Lijun Li The detection of difenidol hydrochloride, which is a drug that is widely used for treating the nausea and vomiting symptoms caused by certain diseases, has been increasingly involved in cases of suicide via overdosing and of drug poisoning in children. A novel electrochemiluminescence (ECL) sensor for the simple and effective detection of difenidol hydrochloride was fabricated by modifying a glassy carbon electrode with three-dimensional carbon nanofibers (3D-CNFs). The 3D-CNFs were synthesized by electrospinning a mixture of montmorillonite (MMT) and polyacrylonitrile, carbonizing the electrospun product...
Source: Sensors - Category: Biotechnology Authors: Tags: Article Source Type: research
CONCLUSIONS: Moderate-certainty evidence shows that context-specific CFR interventions result in increased rates of CPR or defibrillation performed before EMS arrival. It remains uncertain whether this can translate to significantly increased rates of overall patient survival. When possible, further high-quality RCTs that are adequately powered to measure changes in survival should be conducted.The included studies did not consider survival with good neurological function. This outcome is likely to be important to patients and should be included routinely wherever survival is measured.We identified one ongoing study and on...
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Tags: Cochrane Database Syst Rev Source Type: research
CONCLUSIONS: Human errors and adverse hemodynamic events were common with the use of push dose pressors in the emergency department. Adverse hemodynamic events were more common than in previous studies. Future research should determine if push dose pressors improve outcomes and if so, how to safely implement them into practice. PMID: 31270748 [PubMed - as supplied by publisher]
Source: Journal of Medical Toxicology - Category: Toxicology Authors: Tags: J Med Toxicol Source Type: research
Source: National Association of County and City Health Officials (NACCHO). Published: 7/2019. This 29-page report summarizes the results of a scan whose goal was to create a foundational understanding of local health department opioid overdose prevention and response efforts to inform priorities at the local, state, and national levels. Chapters detail Local Opioid Overdose Prevention and Response Activities, Local Health Department Stories from the Field, Next Steps, and Limitations. (PDF)
Source: Disaster Lit: Resource Guide for Disaster Medicine and Public Health - Category: International Medicine & Public Health Source Type: news
Authors: Siggaard CB, Kazankov K, Rødgaard-Hansen S, Møller HJ, Donnelly MC, Simpson KJ, Grønbaek H Abstract The macrophage activation markers, soluble CD163 (sCD163) and soluble mannose receptor (sMR), are associated with liver disease severity and prognosis. We aimed to investigate macrophage activation reflected by sMR and sCD163 in patients with mild and severe paracetamol (PCM) intoxication and effects of antidote treatment in patients and healthy controls. We measured sMR and sCD163 levels by in-house enzyme-linked immunosorbent assays in two independent prospective cohorts of PCM overdos...
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research
Conclusion: Our results suggest that the AT1R mediated hypertensive response to angiotensin II within the NTS in normotensive rats is GABA and NO dependent. Nitric oxide produced within the NTS tonically potentiates local GABA and glutamate release. Introduction The central nervous system network that regulates the level of sympathetic tone and, hence, blood pressure, is located in the brainstem and consists mainly of the rostral ventrolateral medulla (RVLM), the paraventricular nucleus (PVN) of the hypothalamus and the nucleus tractus solitarii (NTS) (Guyenet, 2006). It is well-established that the RVLM, the so-ca...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Dominique E. Martin1,2, Amanda K. Jones1,3, Sambhu M. Pillai1,4, Maria L. Hoffman1,5, Katelyn K. McFadden1,6, Steven A. Zinn1, Kristen E. Govoni1 and Sarah A. Reed1* 1Department of Animal Science, University of Connecticut, Storrs, CT, United States 2Department of Psychology, Providence College, Providence, RI, United States 3Department of Pediatrics, School of Medicine, University of Colorado, Aurora, Aurora, CO, United States 4School of Medicine, Georgetown University, Washington, DC, United States 5Department of Fisheries, Animal and Veterinary Sciences, The University of Rhode Island, Kingston, RI, United St...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
This study was carried out in accordance with the principles of the Basel Declaration and German laws on animal research (TierSchG and TierSchVersV, 2013). The protocol was approved by the LAVES (Niedersächsisches Landesamt für Verbraucherschutz und Lebensmittelsicherheit). Tissue Preparation and Immunocytochemistry The animals were anesthetized with an overdose of ketamin (Essex Tierarznei) and transcardially perfused with 0.9% NaCl solution to remove blood from vessels, followed by 4% paraformaldehyde dissolved in 0.1 M phosphate buffer (PB, pH 7.4). The brains were removed and the two hemispheres separated. ...
Source: Frontiers in Neuroanatomy - Category: Neurology Source Type: research
This study was approved by the Animal Experimental Ethics Committee of Southern Medical University, Guangzhou, China (2014-024). All experiments were performed under protocols to meet the requirements of the Association for Assessment and Accreditation of Laboratory Animal Care International and the Experimental Animal Center of Southern Medical University. Male cynomolgus monkeys (Macaca fascicularis) were used, preliminary power analysis being performed to get the proper sample size for three groups (G∗Power 3.1, Heinrich-Heine-Universität Düsseldorf, Germany; alpha = 0.05, power = 0.95; total N = 20 hem...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
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