Management of Patients in the Context of Zika Virus: ACOG COMMITTEE OPINION, Number 784.

Management of Patients in the Context of Zika Virus: ACOG COMMITTEE OPINION, Number 784. Obstet Gynecol. 2019 Sep;134(3):e64-e70 Authors: Abstract Zika virus is a flavivirus with the potential to cause serious adverse pregnancy and infant outcomes. Although rates of Zika virus infection have decreased in the United States, obstetrician-gynecologists and other health care providers should continue to assess their patients for potential exposure based on travel or sexual history and test symptomatic patients with possible exposure and pregnant women with ongoing exposure regardless of symptoms in accordance with the Centers for Disease Control and Prevention recommendations. Pregnant women and those planning a pregnancy should talk to their health care providers about potential risks before traveling to an area where current or past Zika virus transmission has occurred. Testing recommendations for pregnant women with possible Zika virus exposure differ based on the presence or absence of symptoms of Zika virus infection and the circumstances of possible exposure. If obstetrician-gynecologists or other health care providers identify a patient who has possibly been exposed to the Zika virus and may require testing, they should contact their local or state health department for assistance. Consultation with a maternal-fetal medicine specialist or an infectious disease specialist with expertise in the management of infectious diseases in pregnancy may be usef...
Source: Obstetrics and Gynecology - Category: OBGYN Tags: Obstet Gynecol Source Type: research

Related Links:

In this study, we report for the first time that highly diluted ethanol extracts prepared from basil leaves can effectively inhibit ZIKV replication in Vero E6 cells with a half maximal inhibitory concentration (IC50) value of 1:134. The diluted extract as well as the amount of ethanol that goes into its preparation have been found to be completely non-toxic to the above mentioned cell line. The extract seems to inhibit the virus at the step of attachment and entry into the host cell. The specific inhibition of ZIKV observed using the basil leaf extract suggests a new alternative mode of treatment against flavivirus. Keywo...
Source: Acta Virologica - Category: Infectious Diseases Authors: Tags: Acta Virol Source Type: research
Purpose of review Zika virus (ZIKV) swept through the Americas and led to recognition of its neurotropism. Zika circulation elsewhere in the world, nonvector transmission including maternal–fetal/sexual/transfusion routes, and additional reports on congenital Zika syndrome (CZS) and Guillain–Barré syndrome (GBS) have been published. Recent findings In 2018–2019, ZIKV transmission occurred in Cuba, India, and is suspected to appear sporadically in other countries. Maternal–fetal ZIKV transmission appears to occur in about 26% of ZIKV-infected pregnant women. The US ZIKV Pregnancy and Infa...
Source: Current Opinion in Infectious Diseases - Category: Infectious Diseases Tags: TROPICAL AND TRAVEL-ASSOCIATED DISEASES: Edited by Christina Coyle Source Type: research
Publication date: Available online 4 September 2019Source: Antiviral ResearchAuthor(s): Antonio E. Muruato, Chao Shan, Camila R. Fontes-Garfias, Yang Liu, Qiang Gao, Scott C. Weaver, Pei-Yong ShiAbstractZika virus (ZIKV) has drawn global attention as the etiologic agent of Zika Congenital Syndrome in babies born to infected pregnant women. To prevent future ZIKV outbreaks and protect persons at risk for severe disease, we developed two live-attenuated vaccine (LAV) candidates containing 10- or 20-nucleotide deletions in the 3′UTR of the viral genome (Δ10 and Δ20). After a single-dose immunization, both &D...
Source: Antiviral Therapy - Category: Virology Source Type: research
Publication date: 3 September 2019Source: Cell Reports, Volume 28, Issue 10Author(s): Ahmed O. Hassan, Igor P. Dmitriev, Elena A. Kashentseva, Haiyan Zhao, Douglas E. Brough, Daved H. Fremont, David T. Curiel, Michael S. DiamondSummaryThe teratogenic potential of Zika virus (ZIKV) has made the development of an effective vaccine a global health priority. Here, we generate two gorilla adenovirus-based ZIKV vaccines that encode for pre-membrane (prM) and envelope (E) proteins (GAd-Zvp) or prM and the ectodomain of E protein (GAd-Eecto). Both vaccines induce humoral and cell-mediated immune responses and prevent lethality aft...
Source: Cell Reports - Category: Cytology Source Type: research
Abstract Zika virus (ZIKV) has drawn global attention as the etiologic agent of Zika Congenital Syndrome in babies born to infected pregnant women. To prevent future ZIKV outbreaks and protect persons at risk for severe disease, we developed two live-attenuated vaccine (LAV) candidates containing 10- or 20-nucleotide deletions in the 3'UTR of the viral genome (Δ10 and Δ20). After a single-dose immunization, both Δ10 and Δ20 LAVs protected mice and non-human primates against ZIKV infection. Here, we characterized the stability, safety, and efficacy of the LAVs after continuously culturing th...
Source: Antiviral Research - Category: Virology Authors: Tags: Antiviral Res Source Type: research
CONCLUSIONS The socioeconomic status of pregnant women, especially among the less privileged, influenced the use of protective measures against Zika virus, from the purchase of repellent, clothing, insecticides to other resources in the municipality of Propri á, SE.RESUMO OBJETIVO Avaliar a ades ão de gestantes às medidas de proteção individual contra picadas de mosquitos, recomendadas pelo Ministério da Saúde e investigar os fatores associados à não adoção dessas medidas. MÉTODOS Foram entrevistadas 177 gestantes entre novembro de 2016 e f...
Source: Revista de Saude Publica - Category: International Medicine & Public Health Source Type: research
Abstract In Brazil and in other tropical areas Zika virus infection was directly associated with clinical complications as microcephaly in newborn children whose mothers were infected during pregnancy and the Guillain-Barr é syndrome in adults. Recently, research has been focused on developing new vaccines and drug candidates against Zika virus infection since none of those are available. In order to contribute to vaccine and drug development efforts, it becomes important the understanding of the molecular basis of t he Zika virus recognition, infection and blockade. To this purpose, it is essential the structural d...
Source: Journal of Venomous Animals and Toxins including Tropical Diseases - Category: Tropical Medicine Source Type: research
Clusters of living brain cells are teaching scientists about diseases like autism. With a new finding, some experts wonder if these organoids may become too much like the real thing.
Source: NYT Health - Category: Consumer Health News Authors: Tags: your-feed-science Brain Zika Virus Laboratories and Scientific Equipment Stem Cells Pregnancy and Childbirth Biology and Biochemistry Autism International Space Station Biotechnology and Bioengineering Cell (Journal) University of Ca Source Type: news
In conclusion, ZIKV infection of pregnant sheep results in a change in fetal growth and gestational outcomes.
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
In this study, we asked whether ZIKV infection during pregnancy impairs transplacental transfer of IgG. We enrolled pregnant women with fever or rash in a prospective cohort in Vitoria, Brazil during the recent ZIKV epidemic. ZIKV and dengue virus (DENV)-specific IgG, ZIKV and DENV neutralizing antibodies, and routine vaccine antigen- specific IgG were measured in maternal samples collected around delivery and 20 paired cord blood samples. We concluded that 8 of these mothers were infected with ZIKV during pregnancy and 12 were ZIKV-uninfected. The magnitude of flavivirus-specific IgG, neutralizing antibody, and vaccine-el...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
More News: Centers for Disease Control and Prevention (CDC) | Health Management | Infectious Diseases | OBGYN | Pediatrics | Pregnancy | USA Health | Women | Zika Virus