Antimony resistance in Leishmania (Viannia) braziliensis clinical isolates from atypical lesions associates with increased ARM56/ARM58 transcripts and reduced drug uptake.

CONCLUSIONS: There is a clear correlation between ARM56/58 upregulation and Sb resistance in AT-harbouring patients, suggesting the use of these markers as potential indicators to help the treatment choice and outcome, preventing therapeutic failure. PMID: 31433006 [PubMed - in process]

https://www.ncbi.nlm.nih.gov/pubmed/31433006?dopt=Abstract

Source: Memorias do Instituto Oswaldo Cruz - August 24, 2019 Category: Infectious Diseases Authors: Rugani JN, Gontijo CMF, Frézard F, Soares RP, Monte-Neto RLD Tags: Mem Inst Oswaldo Cruz Source Type: research