Bone health in estrogen-free contraception

This article reviews the effect of estrogens and progestogens on bone and presents new data of the currently approved drospirenone-only pill. The use of progestin-only contraceptives leading to an estradiol level between 30 and 50 pg/ml does not seem to lead to an acc elerate bone loss.
Source: Osteoporosis International - Category: Orthopaedics Source Type: research

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BACKGROUND: Osteoporosis is a skeletal disease. It is still not known which of the risk factors have the greatest impact on osteoporosis development. The study aimed to determine how the selected osteoporosis risk factors contribute to the development of t...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
(International Osteoporosis Foundation) There is an urgent need for guidance and consensus on the methods for, and reporting of, high-resolution peripheral quantitative computed tomography (HR-pQCT) imaging so that different studies can be compared to each other. This position paper, published by a joint working group from IOF, ASBMR and ECTS addresses the need for standardization of techniques and terminology, provides guidance on interpretation and reporting of results, and discusses unresolved issues in the field.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
In this study, we investigated the genetic association of four single nucleotide polymorphisms (SNPs) within the 3’-untranslated regions of vitamin B-related genes, including TCN2 (encodes transcobalamin II), CD320 (encodes transcobalamin II receptor), SLC19A1 (encodes reduced folate carrier protein 1), and SLC19A2 (encodes thiamine carrier 1), with osteoporosis and osteoporotic vertebral compression fracture (OVCF). We recruited 301 postmenopausal women and performed genotyping of CD320 rs9426 C>T, TCN2 rs10418 C>T, SLC19A1 rs1051296 G>T, and SLC19A2 rs16862199 C>T using a polymerizat...
Source: Genes - Category: Genetics & Stem Cells Authors: Tags: Article Source Type: research
Changes in body composition may be the most characteristic feature of aging; age-related loss of muscle and bone mass together with higher adiposity may occur universally during the aging process. Age-related changes in body composition may contribute to a reduced basal metabolic rate that further promotes unfavorable body composition[1]. Although changes in body composition are key features of aging, there may be certain pathological implications when changes go beyond a certain point. Diseases related to body composition have been proposed and well established, i.e., obesity, osteoporosis, and sarcopenia, which was most ...
Source: Maturitas - Category: Primary Care Authors: Source Type: research
Publication date: June 2020Source: European Journal of Surgical Oncology, Volume 46, Issue 6Author(s): Ashleigh Bell, Sheena Waters, Yousif Shanshal, Robert Milligan
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
The importance of preserving musculoskeletal health into old age is marked by the adverse outcomes sarcopenia (loss of muscle mass and function) and osteoporosis (bone loss) may confer such as an increased risk of falls, fractures, frailty, disability and premature death [1]. The role of these metabolically active tissues also extends beyond maintaining mobility and independence. For instance, skeletal muscle insulin resistance has been identified as the largest defect in type II diabetes [2], and the loss of muscle mass and strength correlates with cardiovascular disease in older adults [3].
Source: Maturitas - Category: Primary Care Authors: Source Type: research
ConclusionAll three categories of FRAX ® showed good performance in predicting fractures in Indian postmenopausal women. Thus, it may be utilized for decision regarding treatment and referral for osteoporosis.
Source: Archives of Orthopaedic and Trauma Surgery - Category: Orthopaedics Source Type: research
by Lei Xiong, Kai Zhao, Yu Cao, Hao-Han Guo, Jin-Xiu Pan, Xiao Yang, Xiao Ren, Lin Mei, Wen-Cheng Xiong The nuclear lamina protein lamin A/C is a key component of the nuclear envelope. Mutations in the lamin A/C gene (LMNA) are identified in patients with various types of laminopathy-containing diseases, which have features of accelerated aging and osteoporosis. However, the underlying mechanisms for laminopathy-associated osteoporosis remain largely unclear. Here, we provide evidence that loss of lamin A/C in skeletal muscles, but not osteoblast (OB)-lineage cells, results in not only muscle aging –like deficit but...
Source: PLoS Biology: Archived Table of Contents - Category: Biology Authors: Source Type: research
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
CONCLUSION: On the basis of a broadly based research and participatory development process, a set of indicators has been developed that enables comprehensive evaluation of the regional quality of care of cross-indication, integrated care models focusing on common diseases. In order to be able to increasingly evaluate aspects of care coordination and patient orientation, health promotion as well as nursing, palliative and emergency care in the future, it would be helpful if routine data were collected or made accessible in these areas as well. PMID: 32467041 [PubMed - as supplied by publisher]
Source: Zeitschrift fur Evidenz, Fortbildung und Qualitat im Gesundheitswesen - Category: Health Management Tags: Z Evid Fortbild Qual Gesundhwes Source Type: research
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