Plaque calcification is driven by different mechanisms of mineralization associated with specific cardiovascular risk factors

ConclusionOur results support the hypothesis that the process of atherosclerotic plaque calcification presents a number of similarities with the physiological processes that occur in bone, involving both osteoblasts- and osteoclasts-like arterial cells. Finally, the present study suggests that risk factors, such as hypertension, cigarette smoke and diabetes, can cause the destabilization of the atheromatic plaque acting on calcification process as well as inflammation.
Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research

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CONCLUSIONS: Young adult IS patients in Korea exhibit low awareness and poor management of their risk factors. Although the short-term outcome was relatively favorable in those patients, having SLE was associated with unfavorable outcomes. More attention needs to be paid for improving awareness and controlling risk factors in this population. PMID: 33029967 [PubMed]
Source: Journal of Clinical Neurology - Category: Neurology Tags: J Clin Neurol Source Type: research
CONCLUSION: There were significant differences (P
Source: Puerto Rico Health Sciences Journal - Category: International Medicine & Public Health Tags: P R Health Sci J Source Type: research
ConclusionThe prevalence of reduced mobility among the diabetic older adults in the study is extremely high when compared with results from other studies conducted in Brazil and worldwide. Moreover, a decrease in mobility is one of the main risk factors for falls in older people. Therefore, intervention and health promotion actions should be proposed to maintain and improve the mobility and autonomy of the elderly.
Source: International Journal of Diabetes in Developing Countries - Category: Endocrinology Source Type: research
Authors: Ling Y, Tang S, Cao Y, Fu C Abstract Background: Increasing evidence states that the plasma lipoprotein-associated phospholipase A2 (Lp-PLA2) levels and apolipoprotein particles are regarded as the risk maker for cardiovascular heart disease. Nevertheless, the issue about whether Lp-PLA2 is associated with apolipoprotein particles in individuals who have been diagnosed as stable coronary artery disease (CAD) remains largely unexplored. Method: All 569 participants engaged in this research, who never took lipid-lowering drugs, had been divided into groups by the coronary angiography (CAG), namely, stabl...
Source: Disease Markers - Category: Laboratory Medicine Tags: Dis Markers Source Type: research
Chronic kidney disease (CKD) is a public health threat with impact in cardiovascular risk. All forms of cardiovascular disease and mortality are more common in CKD. Treatment of cardiovascular risk factors, hypertension, dyslipidemia and diabetes is essential for cardiovascular and kidney protection. CKD is a marker of high or very high cardiovascular risk and its presence require early treatment and specific goals. Lifestyle is a pivotal factor, stopping smoking, reducing weight in the overweight or obese, starting regular physical exercise and healthy dietary pattern are recommended. Office BP should be lowered towards 1...
Source: Journal of Hypertension - Category: Cardiology Tags: REVIEWS AND META-ANALYSES Source Type: research
Conclusion: The current study provides the first evidence regarding the status of frailty in older Chinese adults with hypertension.
Source: Journal of Hypertension - Category: Cardiology Tags: ORIGINAL PAPERS: Epidemiology and risk factors Source Type: research
Objectives: Long-term visit-to-visit SBP variability (VVV) predicts cerebro-cardiovascular and renal events in patients with hypertension. Whether VVV predicts hypertension and/or chronic kidney disease is currently unknown. We assessed the role of VVV on the development of hypertension and changes in renal function in patients with type 2 diabetes and normal blood pressure (NBP) in a real-life clinical setting. Methods: Clinical records from 8998 patients with type 2 diabetes, NBP, and normal estimated glomerular filtration rate (eGFR) were analyzed. VVV was measured by SD of the mean SBP recorded in at least four vi...
Source: Journal of Hypertension - Category: Cardiology Tags: ORIGINAL PAPERS: BP in specific clinical conditions Source Type: research
The objective of this study was to determine pCD incidence and risk factors in CEA patients. DESIGN We performed a systematic review and meta-analysis of both randomised and nonrandomised trials following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. DATA SOURCES We searched Cochrane, PubMed/Medline and Embase databases from the date of database inception to 1 December 2018. ELIGIBILITY CRITERIA We selected longitudinal studies including CEA patients with both pre-operative and postoperative cognitive assessments. Primary outcome was pCD incidence, differentiating delayed neurocogn...
Source: European Journal of Anaesthesiology - Category: Anesthesiology Tags: Perioperative medicine Source Type: research
Multiple factors, including increasing incidence, poor knowledge of stroke and lack of effective, noninvasive and convenient stroke risk prediction tools, make it more difficult for precautions against stroke in China. Effective prediction models for stroke may assist to establish better risk awareness and management, healthier lifestyle, and lower stroke incidence for people. The China Health and Retirement Longitudinal Survey was the development cohort. Logistic regression was applied to model's development, in which the candidate variables with statistically significant coefficient were included in the prediction model...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
AbstractAimsFew studies have assessed the prevalence of diabetes and hypertension among pregnant women in China after the implementation of universal two-child policy. Therefore, the aim of the study was to determine the prevalence of diabetes and hypertension from 2016 to 2018 among pregnant women in Jiangsu, China, after the policy implementation.MethodsWe analysed data from pregnant women who delivered their neonates between 2016 and 2018 in the Northern Jiangsu People ’s Hospital. All pregnant women irrespective of their gestation weeks underwent oral glucose intolerance tests in a fasting state.ResultsA total of...
Source: International Journal of Diabetes in Developing Countries - Category: Endocrinology Source Type: research
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