Risks May Outweigh Benefits Of Aspirin Use in Diabetes

According to this study: Aspirin has potential benefits in the primary prevention of cardiovascular disease (CVD) in patients with diabetes, but the risks may outweigh the benefits.The use of low-dose aspirin may need to be individualized, based on a person's risk of CVD and bleeding.
Source: AJN - Category: Nursing Tags: Journal Watch Source Type: research

Related Links:

CONCLUSIONS: To the best of our knowledge, this is the first report of spontaneous bleeding probably caused by Exenatide. The exact pathophysiology, by which the drug can cause spontaneous bleeding, is still not clear and has to be revealed. PMID: 31517602 [PubMed - in process]
Source: Endocrine Regulations - Category: Endocrinology Tags: Endocr Regul Source Type: research
AbstractIntroductionAcute gastrointestinal bleeding (GIB) is a major cause of death in liver cirrhosis. This multicenter study aims to develop and validate a novel and easy-to-access model for predicting the prognosis of patients with cirrhosis and acute GIB.MethodsPatients with cirrhosis and acute GIB were enrolled and randomly divided into the training (n = 865) and validation (n = 817) cohorts. In the training cohort, the independent predictors for in-hospital death were identified by logistic regression analyses, and then a new prognostic model (i.e., CAGIB score) was established. Area under...
Source: Advances in Therapy - Category: Drugs & Pharmacology Source Type: research
Aspirin is arguably a calorie restriction mimetic, in that it boosts the operation of the cellular maintenance processes of autophagy to some degree. Increased autophagy is a feature of many of the interventions, such as calorie restriction, that slow aging in various animal models. Aspirin can extend life in short-lived species. The fact that an ongoing trial shows it to do no such thing in humans is just one more of the many pieces of evidence to demonstrate that short-lived and long-lived species have a very different plasticity of longevity in response to upregulation of stress response systems such as autophagy. The e...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
In recognition of Polycystic Ovary Syndrome (PCOS) Awareness Month, Flo, a digital platform for women’s health and wellbeing, has announced the successful launch of PCOS Health Assistant, a self-assessment tool to help identify the risk of PCOS...
Source: Medgadget - Category: Medical Devices Authors: Tags: Ob/Gyn Source Type: blogs
CONCLUSION: Within the limits of this study, no association between periodontitis and ventilator-associated pneumonia was found. The presence of diabetes and invasive mechanical ventilation duration (> 10 days) were risk factors for pneumonia even after the adjustment of variables. PMID: 31473726 [PubMed]
Source: Journal of the International Academy of Periodontology - Category: Dentistry Tags: J Int Acad Periodontol Source Type: research
Publication date: Available online 1 September 2019Source: The LancetAuthor(s): Deepak L Bhatt, Philippe Gabriel Steg, Shamir R Mehta, Lawrence A Leiter, Tabassome Simon, Kim Fox, Claes Held, Marielle Andersson, Anders Himmelmann, Wilhelm Ridderstråle, Jersey Chen, Yang Song, Rafael Diaz, Shinya Goto, Stefan K James, Kausik K Ray, Alexander N Parkhomenko, Mikhail N Kosiborod, Darren K McGuire, Robert A HarringtonSummaryBackgroundPatients with stable coronary artery disease and diabetes with previous percutaneous coronary intervention (PCI), particularly those with previous stenting, are at high risk of ischaemic even...
Source: The Lancet - Category: General Medicine Source Type: research
ConclusionA high-level of suspicion is required to suspect, diagnose and treat post-RYGB complications. A bariatric on-call rota with appropriately trained personnel is essential.
Source: Obesity Surgery - Category: Surgery Source Type: research
ConclusionIn CF ‐LVAD recipients receiving warfarin, increasing age and distance from clinic are independent predictors of higher TTR, while female sex, type‐2 diabetes, and prior warfarin use are independent predictors of lower TTR.This article is protected by copyright. All rights reserved.
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - Category: Drugs & Pharmacology Authors: Tags: Brief Report Source Type: research
Abstract PURPOSE: The Heart Protection Study 2-Treatment of HDL to Reduce the Incidence of Vascular Events (HPS2-THRIVE) trial of patients at high risk of vascular disease found that adding extended-release niacin-laropiprant to intensive statin-based LDL-lowering therapy had no benefit on cardiovascular outcomes. However, the trial also identified previously unrecognized serious adverse effects (including new-onset diabetes, bleeding, and infection). Our objective was to explore the safety profile of niacin-laropiprant and examine whether any patients were at lower (or higher) risk of its adverse effects. ME...
Source: Clinical Therapeutics - Category: Drugs & Pharmacology Authors: Tags: Clin Ther Source Type: research
FWA Abstract Primary prevention of cardiovascular events with aspirin in patients with elevated cardiovascular risk, including diabetics, is currently under intense discussion. Data from meta-analyses suggests that the efficacy of aspirin in these patients is low, whereas there is a significantly increased bleeding tendency. However, meta-analyses are based on trials that differ in many important aspects, including study selection. Fresh insights were expected from the ASCEND trial, by far the largest primary, randomized, placebo-controlled prevention trial in diabetics without known cardiovascular disease. There ...
Source: Thrombosis and Haemostasis - Category: Hematology Authors: Tags: Thromb Haemost Source Type: research
More News: Aspirin | Bleeding | Cardiology | Cardiovascular | Diabetes | Endocrinology | Heart | Nursing | Study