Glycoprotein Ib clustering in platelets can be inhibited by alpha-linolenic acid as revealed by cryo-electron tomography.

This study provides novel findings on the rapid local rearrangement of the glycoprotein Ib complexes in response to high-shear flow and highlights the mechanism of in vitro inhibition of platelet binding to and rolling on vWF by alpha-linolenic acid. PMID: 31439672 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31439672?dopt=Abstract

Source: Haematologica - August 21, 2019 Category: Hematology Authors: Stivala S, Sorrentino S, Gobbato S, Bonetti NR, Camici GG, Lüscher TF, Medalia O, Beer JH Tags: Haematologica Source Type: research