Placenta-derived extracellular vesicles induce preeclampsia in mouse models.

Placenta-derived extracellular vesicles induce preeclampsia in mouse models. Haematologica. 2019 Aug 22;: Authors: Han C, Wang C, Chen Y, Wang J, Xu X, Hilton T, Cai W, Zhao Z, Wu Y, Li K, Houck K, Liu L, Sood AK, Wu X, Xue F, Li M, Dong JF, Zhang J Abstract Preeclampsia is a pregnancy-induced condition that impairs mother's health and results in pregnancy termination or premature delivery. Elevated levels of placenta-derived extracellular vesicles in the circulation have been consistently associated with preeclampsia, but whether placenta-derived extracellular vesicles induce preeclampsia or are merely the product of preeclampsia is not known. Guided by a small cohort study of preeclampsia patients, we examined the impact of placenta-derived extracellular vesicles on the pathogenesis of preeclampsia in mouse models. We found that placenta-derived extracellular vesicles were detected in pregnant C56BL/6J mice with a peak level of 3.8+/-0.9x107/ml in 17-18 days post-coitum. However, these pregnant mice developed hypertension and proteinuria only after being infused with these vesicles purified from injured placenta. These injured placenta-released extracellular vesicles disrupted the endothelial integrity and induced vasoconstriction. Enhancing the clearance of extracellular vesicles prevented the development of the extracellular vesicle-induced preeclampsia in mice. Our results demonstrate a causal role of placenta-derived extracellu...
Source: Haematologica - Category: Hematology Authors: Tags: Haematologica Source Type: research