Efficacy of triptans for the treatment of acute migraines: a quantitative comparison based on the dose-effect and time-course characteristics

ConclusionsThis study evaluated the efficacy characteristics of seven kinds of triptans and their different dosage forms. The present findings provide necessary quantitative information for migraine medication guidelines.
Source: European Journal of Clinical Pharmacology - Category: Drugs & Pharmacology Source Type: research

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Do any of you have a good method of prescribing home SPG for a migraine abortive? I’ve prescribed lidocaine drops successfully but I’m not sure what I can prescribe for equipment to administer it (dropper, syringes, etc). Thanks!
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Pain Medicine Source Type: forums
Abstract Advanced analyses of electroencephalography (EEG) are rapidly becoming an important tool in understanding the brain's processing of pain. To date, it appears that none have been explored as a way of distinguishing between migraine patients with aura (MWA) vs. those without aura (MWoA). In this work, we apply a mixture of predictive, e.g., classification methods and attribute-selection techniques, and traditional explanatory, e.g., statistical, analyses on functional connectivity measures extracted from EEG signal acquired from at-rest participants (N = 52) during their interictal period and ...
Source: Annals of Biomedical Engineering - Category: Biomedical Engineering Authors: Tags: Ann Biomed Eng Source Type: research
ConclusionConsistent with research in middle and older adults, physical health conditions are associated with increased risk for the onset of suicidal thoughts and behaviors in adolescents. Mental health screening for adolescents with chronic medical conditions may help parents and physicians identify suicidality early.
Source: Social Psychiatry and Psychiatric Epidemiology - Category: Psychiatry Source Type: research
AbstractPurpose of ReviewSystematic review of angiotensin-converting enzyme inhibitors (ACE inhibitors) and angiotensin receptor blockers (ARB) in the prophylactic treatment of adults with migraine. To identify gaps in research and provide guidance for future clinical trials.Recent FindingsA search was completed using PubMed, MEDLINE, Embase, and the Cochrane Library January 1, 1990 through December 31, 2017. The following are keywords used in the search: migraine, migraine prophylaxis/prevention, renin-angiotensin-aldosterone system, RAAS, ACE inhibitors, angiotensin-converting enzyme inhibitors: quinapril, perindopril, r...
Source: Current Pain and Headache Reports - Category: Neurology Source Type: research
Acupuncture might help to reduce opioid use49 for pain management because it has been shown to have clinical effects on several prevalent chronic pain conditions75,76 including osteoarthritis of the knee,78 chronic back pain,10 tension-type headache52 and migraine,45 with effect sizes comparable to other common pharmacological opioid alternatives.7 In addition, acupuncture has shown to be relatively safe,48,79 and it is used by patients.17 It has also been shown to be cost-effective within accepted thresholds.
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research
Publication date: 10 September 2019Source: Cell Reports, Volume 28, Issue 11Author(s): Maggie W. Waung, Elyssa B. Margolis, Annabelle R. Charbit, Howard L. FieldsSummaryMigraines are a major health burden, but treatment is limited because of inadequate understanding of neural mechanisms underlying headache. Imaging studies of migraine patients demonstrate changes in both pain-modulatory circuits and reward-processing regions, but whether these changes contribute to the experience of headache is unknown. Here, we demonstrate a direct connection between the ventrolateral periaqueductal gray (vlPAG) and the ventral tegme...
Source: Cell Reports - Category: Cytology Source Type: research
A study has found that women with menopause symptoms are nearly twice as likely to have chronic pain diagnoses, such as fibromyalgia, migraine, and back pain.
Source: WebMD Health - Category: Consumer Health News Source Type: news
AbstractBackgroundMigraine is a complex neurological disorder that affects a significant percentage of the human species, from all geographic areas and cultures. Cognitive symptoms and dysfunctions are interim and disabling components of this disorder and may be related to the brain processes underlying the pathophysiology. Yet they are often undervalued by clinicians. In this review, we present the different types of cognitive dysfunctions associated with migraine and the mechanisms that are potentially causing them.FindingsWhile reversible attack-related cognitive dysfunction seems extremely consistent and likely related...
Source: Current Pain and Headache Reports - Category: Neurology Source Type: research
We report a 51-year-old gentleman with composite pheochromocytoma, which is rarer than pheochromocytoma, presenting as severe back pain and lactic acidosis.
Source: Indian Journal of Nephrology - Category: Urology & Nephrology Authors: Source Type: research
Rimegepant, a medicine belonging to a new class of migraine treatments, relieves pain and other symptoms in patients with moderate or severe migraine pain, research published in  The New England Journal of Medicine has shown.
Source: The Pharmaceutical Journal - Category: Drugs & Pharmacology Source Type: research
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