Polygalasaponin F treats mice with pneumonia induced by influenza virus

AbstractBackgroundInfluenza is an acute viral respiratory illness that causes high morbidity and mortality globally. Therapeutic actions are limited to vaccines and a few anti-viral drugs.Polygala(P.) japonica herba is rich in Polygalasaponin F (PSF, C53H86O23), used for acute bronchitis, pharyngitis, pneumonia, amygdalitis, and respiratory tract infections treatment in China. Hypercytokinemia is often correlated with severe pneumonia caused by several influenza viruses. PSF was reported to have anti-inflammatory effects and its mechanism is associated with the nuclear factor (NF)- κB signaling pathway. The action of PSF to alleviate pulmonary inflammation caused by influenza A virus (IAV) infection requires careful assessment. In the present study, we evaluated the effect and mechanism of PSF on mice with pneumonia caused by influenza H1N1 (A/FM/1/47).MethodsMice were infected intranasally with fifteen 50% mouse lethal challenge doses (MLD50) of influenza virus. BALB/c mice were treated with PSF or oseltamivir (oral administration) for 2  h post-infection and received concomitant treatment for 5 days after infection. On day 6 post-infection, 10 mice per group were killed to collect related samples, measure body weight and lung wet weight, and detect the viral load, cytokine, prostaglandins, pathological changes, and cell pathway p rotein expression in the lungs. In addition, the survival experiments were carried out to investigate the survival of mice. The ex...
Source: Inflammopharmacology - Category: Drugs & Pharmacology Source Type: research

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In this study, we investigate the time-frequency analysis (TFA) method, together with the wavelet filtering of the Daubechies method and the relative power spectrum analysis of the Fourier Welch method to extract and analyse the TRBA caused by the 2008 Wenchuan Ms 8.0 earthquake and the TRA of the 2013 Minxian-Zhangxian Ms 6.6 earthquake using data concerning the brightness temperature of a black body (TBB) from the Fengyun-2 series of geostationary meteorological satellites developed by China. The result showed that this method can effectively extract and analyse the TRBA caused by the Wenchuan earthquake and the TRA of t...
Source: Advances in Space Research - Category: Science Source Type: research
Journal Name: Clinical Chemistry and Laboratory Medicine (CCLM) Issue: Ahead of print
Source: Clinical Chemistry and Laboratory Medicine - Category: Laboratory Medicine Source Type: research
Authors: Ichihara E, Miyahara N, Maeda Y, Kiura K Abstract Systemic therapy for advanced non-small cell lung cancer (NSCLC) has dramatically changed in the latest 15 years. Molecular-targeted therapy has brought about an era of precision medicine, and immune checkpoint inhibitors have brought hope for a cure for advanced NSCLC. In the wake of this remarkable advancement, lung cancer with comorbid interstitial pneumonia (IP) has been completely left behind, as most clinical trials exclude patients with comorbid IP. IP, especially idiopathic pulmonary fibrosis (IPF), is often accompanied by lung cancer, and acute exa...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Conclusion: Our study first implied that the A variant of rs17687727 in TGFBRAP1 influenced the susceptibility to ATDILI in first-line antituberculosis combination treatment in the Han Chinese population in a dependent manner. PMID: 31534460 [PubMed]
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Abstract Prostate cancer (PCa) incidence has been rising in Chinese population. Current PSA-based biopsy has limited positive rate. Our research focused on development of serum markers for the diagnosis of PCa in patients with elevated PSA. miRNAs are found to be aberrantly expressed in many types of cancer. They are readily detectable in plasma and serum. Currently, miRNAs are being evaluated as potential prognostic and diagnostic tools for many types of cancer. We first profiled global serum miRNAs in a pilot set of PCa and benign prostatic hyperplasia (BPH) cases undergoing TRUS-guided prostate biopsy due to el...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
This study aimed to evaluate the efficiency of circRNAs in the diagnosis and prognosis for lung cancer in China. 2122 Chinese individuals were enrolled in this investigation for assessment of diagnostic value and examination of prognostic analysis. In the diagnostic analysis, the pooled sensitivity, specificity, PLR, NLR, DOR, and AUC of the sROC curve with their 95% CIs were 0.80 (95%CI: 0.74-0.84), 0.80 (95%CI: 0.73-0.86), 3.97 (95%CI: 2.80-5.62) and 0.26 (95%CI: 0.19-0.34), 15.51 (95%CI: 8.76-24.47), and 0.85 (95%CI: 0.82-0.88), respectively. As for the prognostic power of circRNAs, lung cancer patients with higher expr...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
Publication date: Available online 19 September 2019Source: Chinese Chemical LettersAuthor(s): Ni Yan, Jiale Song, Fengyan Wang, Longwang Kan, Jiahang Song, Weiling Wang, Wenqiang Ma, Weidong Zhang, Gang HeAbstractTwo highly emissive pyrenoviologen derivatives were synthesized and used to fabricate fluorescent sensors for detection of picric acid (PA) with good sensitivity and selectivity. The sensitivity of the sensor was attributed to the specific electrostatic association effect of the cationic pyrenoviologens to the picrate anions, which also gave the sensor special selectivity among other compounds with similar struct...
Source: Chinese Chemical Letters - Category: Chemistry Source Type: research
Publication date: Available online 19 September 2019Source: Chinese Chemical LettersAuthor(s): Xia Mi, Yuanfang Kong, Jingyu Zhang, Chao Pi, Xiuling CuiABSTRACTThe visible light promoted C-H sulfonylmethylation of imidazopyridines with easily accessible bromomethyl sulfones under mild reaction conditions was described. This protocol provides an effective and practical access to sulfonylmethylated imidazopyridines with good functional group tolerance. The desired products were provided in moderate to excellent yields for 50 examples at room temperature. The method could also be an attractive strategy to install a methyl gro...
Source: Chinese Chemical Letters - Category: Chemistry Source Type: research
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Source: Chinese Chemical Letters - Category: Chemistry Source Type: research
Publication date: Available online 19 September 2019Source: Chinese Chemical LettersAuthor(s): Jing Zheng, Dandan Song, Hong Chen, Jingli Xu, Njud S. Alharbi, Tasawar Hayat, Min ZhangAbstractThe exploitation of multifunctional nanocomposites is highly desired in environmental monitoring, biosensors, and medical diagnosis. In this paper, a simple approach has been proposed to fabricate MoS2 decorated N-doped carbon nanotubes (NCNTs@MoS2) hybrid composites as efficient peroxidase-like mimics. The combination of the MoS2 and N-doped carbon nanotubes (NCNTs) brings about an enhanced synergistic effect, leading to remarkably de...
Source: Chinese Chemical Letters - Category: Chemistry Source Type: research
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